Document Detail


Tissue and developmental specificity of a polysialo-ganglioside species in the amphibian Xenopus.
MedLine Citation:
PMID:  8969459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Xenopus embryos contain a considerable amount of a polysialo-ganglioside not yet fully characterized; in this paper, we will refer to it as ganglioside XI. Preliminary experiments indicate asialo-GMI as the core structure of the ganglioside XI and palmitic and oleic acid as the fatty acids of the ceramide moiety. Further analyses by comparative 2D-TLC with adult fish and chick embryo brains indicate the pentasialilated ganglioside GP1c as the possible structure of XI. In the adult Xenopus, XI characterizes the ganglioside pattern of the central nervous system while is absent in all the other tested tissues. At least two other more polar (presumably richer in sialic acid) bands are often visible under XI, both in embryos and in brain and spinal cord tissues of adult Xenopus. The persistence of polysialo-gangliosides in the brain and spinal cord of adult amphibians could serve to guarantee a proper functioning of the central nervous system at low body temperature.
Authors:
G Bernardini; A M Rizzo; R Gornati; F Rossi; B Berra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international     Volume:  20     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-04-03     Completed Date:  1997-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  667-72     Citation Subset:  IM    
Affiliation:
Istituto di Fisiologia Generale e Chimica Biologica, Università di Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry
Carbohydrate Sequence
Chick Embryo
Embryo, Nonmammalian / chemistry
G(M1) Ganglioside / analysis
Gangliosides / chemistry,  isolation & purification,  physiology*
Glycolipids / analysis
Molecular Sequence Data
Oleic Acid / analysis
Organ Specificity
Palmitic Acid / analysis
Species Specificity
Spinal Cord / chemistry
Tilapia / metabolism*
Xenopus laevis / embryology,  metabolism*
Chemical
Reg. No./Substance:
0/Gangliosides; 0/Glycolipids; 112-80-1/Oleic Acid; 37758-47-7/G(M1) Ganglioside; 57-10-3/Palmitic Acid; 71012-19-6/asialo GM1 ganglioside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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