Document Detail


Tissue deposition and residue depletion of melamine in fattening pigs following oral administration.
MedLine Citation:
PMID:  24397789     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The adulteration of animal feed as well as milk products with melamine has led to concerns about the ability to establish appropriate withdrawal intervals to ensure food safety. Two experiments were conducted in this study. The first was to investigate the deposition and depletion of melamine in blood and tissues of pigs exposed to adulterated feed with high doses of melamine. A total of 500 or 1000 mg kg(-1) melamine was added to the diet for fattening pigs (initial BW = ±60.24 kg). Melamine residues were detected in tissues (brain, duodenum, liver, heart, muscle and kidney) by LC-MS/MS. Dose-dependent effects were found between melamine residual concentration and its dose in feed. Five days after the withdrawal of melamine from the diets, the residue concentration in tissues fell below 2.5 mg kg(-1). In the second experiment, blood samples were taken at different time points from fattening pigs (BW = 100 kg) fed with adulterated feed with 1000 mg kg(-1) of melamine for 42 days. Results from the pharmacokinetics analysis showed that it would take 83 h for the melamine level in plasma depleting to the safe level of 50 ng ml(-1) after an expose of 1000 mg kg(-1) melamine contaminated feed for 42 days.
Authors:
Wei Wang; Hong Chen; Bing Yu; Xiangbing Mao; Daiwen Chen
Related Documents :
6729259 - Protective effect of choline theophyllinate on histamine, acetylcholine, and propranolo...
6122579 - Cardiovascular effects of theophylline. partial attenuation by beta-blockade.
9570449 - Effects of phosphodiesterase inhibitors and salbutamol on microvascular leakage in guin...
12568539 - Simple and rapid determination of thiabendazole, imazalil, and o-phenylphenol in citrus...
14973299 - Similarity of insulin detemir pharmacokinetics, safety, and tolerability profiles in he...
1974189 - Inhibition and induction of theophylline metabolism by 8-methoxypsoralen. in vivo study...
3755409 - Effects of decapeptide of mammalian bombesin and neuromedin b on pancreatic exocrine se...
12577159 - Metabolic changes detected by microdialysis during endotoxin shock and after endotoxin ...
6546919 - The fate of drotaverine-acephyllinate in rat and man. ii. human pharmacokinetics of dro...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-8
Journal Detail:
Title:  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     Volume:  -     ISSN:  1944-0057     ISO Abbreviation:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485040     Medline TA:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Multisensory integration in schizophrenia: a behavioural and event-related potential study.
Next Document:  Genetic basis of coaggregation receptor polysaccharide biosynthesis in Streptococcus sanguinis and r...