Document Detail


Tissue blood flow and blood flow distribution after administration of dextran 70, dihydroergotamine and their combination. A study in dogs using the radioactive microsphere technique.
MedLine Citation:
PMID:  6195856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The radioactive microsphere technique was used to measure tissue blood flow after administration of dextran 70 and dihydroergotamine, both separate and in combination, in normotensive dogs. Dextran 70 increased cardiac, output and tissue blood flow to most organs. Unchanged blood flow after dextran 70 to CNS, liver (hepatic artery blood flow), adrenals, genitals, uterus and lungs (bronchial artery and arteriovenous shunts) was found. Dihydroergotamine administration did not alter cardiac output. Tissue blood flow to pancreas and thyroid was reduced and CNS-tissue blood flow increased. Heart tissue blood flow was unaffected. When dihydroergotamine was given after dextran 70 had been infused, tissue blood flow returned to baseline values--except for pancreas and thyroid, where tissue blood flow was reduced, and CNS-tissue, where blood flow was increased. When dextran 70 was infused after dihydroergotamine, cardiac output and tissue blood flow remained mainly unchanged.
Authors:
B Lindblad; D Bergqvist
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta chirurgica Scandinavica     Volume:  149     ISSN:  0001-5482     ISO Abbreviation:  Acta Chir Scand     Publication Date:  1983  
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906530     Medline TA:  Acta Chir Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Circulation / drug effects*
Cardiac Output / drug effects
Cerebrovascular Circulation / drug effects
Coronary Circulation / drug effects
Dextrans / pharmacology*
Dihydroergotamine / pharmacology*
Dogs
Female
Hemodynamics / drug effects*
Male
Microspheres
Models, Biological
Chemical
Reg. No./Substance:
511-12-6/Dihydroergotamine; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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