| Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. | |
| | |
MedLine Citation:
|
PMID: 21533227 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Obesity is characterized by accumulation of excess body fat, while lipodystrophy is characterized by loss or absence of body fat. Despite their opposite phenotypes, these two conditions both cause ectopic lipid storage in non-adipose tissues, leading to lipotoxicity, which has health-threatening consequences. The exact mechanisms underlying ectopic lipid storage remain elusive. Here we report the analysis of a Drosophila model of the most severe form of human lipodystrophy, Berardinelli-Seip Congenital Lipodystrophy 2, which is caused by mutations in the BSCL2/Seipin gene. In addition to reduced lipid storage in the fat body, dSeipin mutant flies accumulate ectopic lipid droplets in the salivary gland, a non-adipose tissue. This phenotype was suppressed by expressing dSeipin specifically within the salivary gland. dSeipin mutants display synergistic genetic interactions with lipogenic genes in the formation of ectopic lipid droplets. Our data suggest that dSeipin may participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis to prevent ectopic lipid droplet formation. In summary, we have demonstrated a tissue-autonomous role of dSeipin in ectopic lipid storage in lipodystrophy. |
| | |
Authors:
|
Yuan Tian; Junfeng Bi; Guanghou Shui; Zhonghua Liu; Yanhui Xiang; Yuan Liu; Markus R Wenk; Hongyuan Yang; Xun Huang |
Related Documents
:
|
20981877 - The effects of dietary fish oil on inflammation, fibrosis and oxidative stress associat... 7441107 - Use of the ames test in assessing the relation of dietary lipid and antioxidants to n-2... 4032077 - Comparative study of the atherogenecity of dietary trans, saturated and unsaturated fat... 6096527 - Differential effects of dietary eicosapentaenoic and docosahexaenoic fatty acids on low... 2231027 - Response of hormones modulating plasma cholesterol to dietary casein or soy protein in ... 17122327 - Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury. |
Publication Detail:
|
Type: Journal Article Date: 2011-04-14 |
Journal Detail:
|
Title: PLoS genetics Volume: 7 ISSN: 1553-7404 ISO Abbreviation: PLoS Genet. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101239074 Medline TA: PLoS Genet Country: United States |
Other Details:
|
Languages: eng Pagination: e1001364 Citation Subset: IM |
Affiliation:
|
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reprogramming of Embryonic Human Fibroblasts into Fetal Hematopoietic Progenitors by Fusion with Hum...
Next Document: Early growth response gene-2 (egr-2) regulates the development of B and T cells.