| Tissue angiotensin-converting enzyme in imposed and physiological flow-related arterial remodeling in mice. | |
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MedLine Citation:
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PMID: 15031129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test whether membrane-bound angiotensin I-converting enzyme (t-ACE) is involved in arterial remodeling, we applied unilateral carotid artery (CA) ligation and studied uterine arteries (UA) before, during, and after pregnancy in t-ACE-/- and t-ACE+/+ mice. RESULTS- In CA of t-ACE-/- mice, blood pressure, outer diameter (D), and medial cross-sectional area (mCSA) were reduced, whereas blood flow (BF) and the number of medial cells (mC) were not modified. In the ligated CA, mCSA and number of mC were increased while outer D and distensibility were reduced. These changes were significantly less pronounced in t-ACE-/- than t-ACE+/+ mice. In UA of t-ACE-/- mice, D was larger and mCSA was unaltered. At term pregnancy, D and mCSA of the UA were reversibly increased. Structural changes of UA during and after pregnancy were comparable in both strains. CONCLUSIONS: t-ACE contributes to arterial structure and remodeling. It plays a major role in hyperplastic inward remodeling of the CA imposed by blood flow cessation, but it is not essential for outward hypertrophic and subsequent inward hypotrophic remodeling of the UA during and after pregnancy. |
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Authors:
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Rob H P Hilgers; Paul M H Schiffers; Wendy M Aartsen; Gregorio E Fazzi; Jos F M Smits; Jo G R De Mey |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2004-03-18 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 24 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-10 Completed Date: 2004-10-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 892-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology & Toxicology, Universiteit Maastricht, Maastricht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Angiotensin II / physiology Animals Arteries / anatomy & histology, enzymology Carotid Arteries / enzymology*, pathology Female Hemorheology* Hyperplasia Hypertrophy Ligation Male Membrane Proteins / deficiency, genetics, physiology* Mice Mice, Inbred C57BL Peptidyl-Dipeptidase A / chemistry, deficiency, genetics, physiology* Postpartum Period Pregnancy Protein Structure, Tertiary Sequence Deletion Stress, Mechanical Uterus / blood supply* |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 11128-99-7/Angiotensin II; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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