Document Detail

Tissue angiotensin-converting enzyme in imposed and physiological flow-related arterial remodeling in mice.
MedLine Citation:
PMID:  15031129     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test whether membrane-bound angiotensin I-converting enzyme (t-ACE) is involved in arterial remodeling, we applied unilateral carotid artery (CA) ligation and studied uterine arteries (UA) before, during, and after pregnancy in t-ACE-/- and t-ACE+/+ mice. RESULTS- In CA of t-ACE-/- mice, blood pressure, outer diameter (D), and medial cross-sectional area (mCSA) were reduced, whereas blood flow (BF) and the number of medial cells (mC) were not modified. In the ligated CA, mCSA and number of mC were increased while outer D and distensibility were reduced. These changes were significantly less pronounced in t-ACE-/- than t-ACE+/+ mice. In UA of t-ACE-/- mice, D was larger and mCSA was unaltered. At term pregnancy, D and mCSA of the UA were reversibly increased. Structural changes of UA during and after pregnancy were comparable in both strains.
CONCLUSIONS: t-ACE contributes to arterial structure and remodeling. It plays a major role in hyperplastic inward remodeling of the CA imposed by blood flow cessation, but it is not essential for outward hypertrophic and subsequent inward hypotrophic remodeling of the UA during and after pregnancy.
Rob H P Hilgers; Paul M H Schiffers; Wendy M Aartsen; Gregorio E Fazzi; Jos F M Smits; Jo G R De Mey
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2004-03-18
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  24     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-10     Completed Date:  2004-10-14     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  892-7     Citation Subset:  IM    
Department of Pharmacology & Toxicology, Universiteit Maastricht, Maastricht, The Netherlands.
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MeSH Terms
Angiotensin II / physiology
Arteries / anatomy & histology,  enzymology
Carotid Arteries / enzymology*,  pathology
Membrane Proteins / deficiency,  genetics,  physiology*
Mice, Inbred C57BL
Peptidyl-Dipeptidase A / chemistry,  deficiency,  genetics,  physiology*
Postpartum Period
Protein Structure, Tertiary
Sequence Deletion
Stress, Mechanical
Uterus / blood supply*
Reg. No./Substance:
0/Membrane Proteins; 11128-99-7/Angiotensin II; EC A

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