| Tissue Resonance Interaction Method (TRIMprob) has the potential to be used alongside the recognized tests in the screening protocols for prostate cancer. | |
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MedLine Citation:
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PMID: 19456986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to evaluate the accuracy of the magnetic induction technique with a nonlinear tunable oscillator (the Tissue Resonance Interaction Method [TRIMprob]) in the diagnosis of prostate cancer (CaP). Overall, 148 men were split into two groups (patients at risk of CaP [Group 1] and controls [Group 2]) and evaluated with the TRIMprob. Group 1 consisted of 100 patients (mean age: 63.8 +/- 7.2 years) with elevated prostate-specific antigen (>4 ng/mL) levels and/or abnormal digital rectal examination. Eleven patients (Group 2a, mean age: 59.5 +/- 7.3) with previously biopsy-proven CaP served as positive controls. In addition, 37 voluntary men (Group 2b, mean age: 39.8 +/- 10.4) with normal prostate-specific antigen and digital rectal examination without lower urinary tract symptoms served as negative controls. Non-linear resonance was analyzed at 465 MHz and a cut-off value of 40 units was detected as the resonance value for the best threshold to distinguish benign conditions from CaP after transrectal ultrasonography-guided biopsy with a standard 10-12 core technique in Group 1. Mean resonance values (+/-standard deviation) with the TRIMprob examination for patients in Groups 1 and 2b were 36.72 +/- 22.35 and 73.64 +/- 10.06, respectively, whereas for patients in Group 2a, it was 13.73 +/- 12.12 (P < 0.01). Sensitivity, specificity, positive and negative predictive values of the TRIMprob using the study cohort of Group 1 were found as 76%, 61.3%, 39.6% and 88.5%, respectively. Despite some technical limitations, the non-invasive TRIMprob examination may have a role in screening protocols for CaP. |
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Authors:
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Ozgur Gokce; Oner Sanli; Artur Salmaslioglu; Atadan Tunaci; Cavit Ozsoy; Faruk Ozcan |
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Publication Detail:
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Type: Journal Article Date: 2009-05-12 |
Journal Detail:
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Title: International journal of urology : official journal of the Japanese Urological Association Volume: 16 ISSN: 1442-2042 ISO Abbreviation: Int. J. Urol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-03 Completed Date: 2009-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440237 Medline TA: Int J Urol Country: Australia |
Other Details:
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Languages: eng Pagination: 580-3 Citation Subset: IM |
Affiliation:
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Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biopsy, Needle Electromagnetic Fields* Humans Male Mass Screening Middle Aged Prostate / pathology* Prostate-Specific Antigen / blood Prostatic Neoplasms / blood, pathology* Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.77/Prostate-Specific Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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