Document Detail

Tissue factor-bearing microparticles and thrombus formation.
MedLine Citation:
PMID:  21252066     Owner:  NLM     Status:  MEDLINE    
Blood microparticles are vesicular structures with a diameter of 100 to 1000 nm that are present in the blood of normal subjects and in patients with various diseases. These microparticles are derived from cells that circulate in the blood and cells associated with the blood vessel wall. Microparticle membranes retain the protein receptors of their parent cells and may retain RNAs and other cytosolic content. On the basis of surface protein expression, microparticles are known to be derived from platelets, granulocytes, monocytes, endothelial cells, smooth muscle cells, and tumor cells. Only a subpopulation of these microparticles expresses tissue factor.
Jeffrey I Zwicker; Cameron C Trenor; Barbara C Furie; Bruce Furie
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-01-20
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  31     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-17     Completed Date:  2011-05-18     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  728-33     Citation Subset:  IM    
Division of Hemostasis, Harvard Medical School, Thrombosis Beth Israel Deaconess Medical Center, 330 Brookline Ave E/CLS 903, Boston, MA 02215, USA.
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MeSH Terms
Blood Coagulation*
Cell-Derived Microparticles / metabolism*
Particle Size
Thromboplastin / metabolism*
Thrombosis / blood*
Grant Support
Reg. No./Substance:

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