Document Detail

Tissue Doppler time intervals and derived indices in hypoplastic left heart syndrome.
MedLine Citation:
PMID:  22157969     Owner:  NLM     Status:  Publisher    
AIMS: To describe tissue Doppler time intervals and derived indices in hypoplastic left heart syndrome (HLHS) across surgical stages, taking account of age-related changes in the heart rate. Correlation of the myocardial performance index (MPI) and the systolic to diastolic (S:D) time ratio with other echocardiographic and magnetic resonance imaging (MRI) measures of cardiac performance. METHODS AND RESULTS: Fifty-seven patients at different stages of HLHS palliation were studied prospectively using tissue Doppler imaging of the right ventricular free wall, with simultaneous cardiac MRI in the majority. Both isovolumic contraction time and isovolumic relaxation time were prolonged compared with the normal left and right ventricle: median (range) z-scores for the tricuspid annulus 1.9 (-1.2 to 9.3) and 1.3 (-2.0 to 5.5), respectively. When adjusted for heart rate, the ejection, systolic, and diastolic times in HLHS were not significantly different from published normal data. The MPI was increased at all surgical stages in HLHS. Neither MPI nor heart rate-specific S:D time ratio z-score correlated with MRI ejection fraction or indexed cardiac output when the confounding effect of significant tricuspid regurgitation was taken into consideration. CONCLUSION: The prolongation in isovolumic relaxation and contraction times may be due to adaptation or reduced myocardial performance. Differences in the S:D time ratio between surgical stages can be accounted for by the heart rate alone. Neither MPI z-score nor S:D z-score correlated with MRI or other echocardiographic indices of systolic or diastolic function with the exception of a negative correlation between central venous pressure and S:D ratio z-score.
Hannah R Bellsham-Revell; Shane M Tibby; Aaron J Bell; Owen I Miller; Reza Razavi; Gerald F Greil; John M Simpson
Related Documents :
22554459 - Comparison of selvester qrs score with magnetic resonance imaging measured infarct size...
2295749 - Comprehensive doppler assessment of right ventricular diastolic function in cardiac amy...
1747279 - Assessment of right and left ventricular function in terms of force development with ge...
17098139 - Effect of preload reduction by hemodialysis on myocardial ultrasonic characterization, ...
15562259 - Detection of ischemia and new insight into left ventricular physiology by strain dopple...
1868539 - Evaluation of a theoretical doppler index to noninvasively estimate peak dp/dt using co...
10050799 - Mri of supracristal ventricular septal defects.
6650169 - Postinfarction cardiac rupture. a pathogenetic consideration in eight cases.
12875769 - Ultrasound tissue characterization detects preclinical myocardial structural changes in...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-8
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  -     ISSN:  1532-2114     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Imaging Sciences and Biomedical Engineering, Rayne Institute, Lambeth Wing, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prognostic and predictive value of a malignancy-risk gene signature in early-stage non-small cell lu...
Next Document:  The Evolution of a Statewide Network: The Bay Area Simulation Collaborative.