| Tissue Doppler imaging following paediatric cardiac surgery: early patterns of change and relationship to outcome. | |
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MedLine Citation:
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PMID: 19447805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, tissue Doppler imaging (TDI) was used to assess changes in ventricular function following repair of congenital heart defects. The relationship between TDI indices, myocardial injury and clinical outcome was explored. Forty-five children were studied; 35 with cardiac lesions and 10 controls. TDI was performed preoperatively, on admission to paediatric intensive care unit (PICU) and day 1. Regional myocardial Doppler signals were acquired from the right ventricle (RV), left ventricle (LV) and septum. TDI indices included: peak systolic velocities, isovolumetric velocities (IVV) and isovolumetric acceleration (IVA). Preoperatively, bi-ventricular TDI velocities in the study group were reduced compared with normal controls. Postoperatively, RV velocities were significantly reduced and this persisted to day-1 (PreOp vs. PICU and day-1: 7.7+/-2.2 vs. 3.4+/-1.0, P<0.0001 and 3.55+/-1.29, P<0.0001). LV velocities initially declined but recovered towards baseline by day-1 (PreOp vs. PICU: 5.31+/-1.50 vs. 3.51+/-1.23, P<0.0001). Isovolumetric parameters in all regions were reduced throughout the postoperative period. Troponin-I release correlated with longer X-clamp times (r=0.82, P<0.0001) and reduced RV velocities (r=0.42, P=0.028). Reduced pre- and postoperative LV velocities correlated with longer ventilation (PreOp: r=0.54, P=0.002; PostOp: r=0.42, P=0.026). This study identified reduced postoperative RV velocities correlated with myocardial injury while reduced LV TDI correlated with longer postoperative ventilation. |
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Authors:
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Antony Vassalos; Stuart Lilley; David Young; Edward Peng; Kenneth MacArthur; James Pollock; Fiona Lyall; Mark H D Danton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-15 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 9 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-24 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 173-7 Citation Subset: IM |
Affiliation:
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Royal Hospital for Sick Children, Yorkhill Division, Glasgow, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Cardiac Surgical Procedures* / adverse effects Case-Control Studies Child, Preschool Echocardiography, Doppler* Heart Septal Defects / physiopathology, surgery*, ultrasonography* Humans Infant Myocardial Contraction Myocardium / metabolism, pathology Predictive Value of Tests Respiration, Artificial / adverse effects Time Factors Treatment Outcome Troponin I / blood Ventricular Function, Left Ventricular Function, Right |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Troponin I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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