| Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy. | |
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MedLine Citation:
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PMID: 11447072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Left ventricular hypertrophy (LVH), the clinical hallmark of familial hypertrophic cardiomyopathy (FHCM), is absent in a significant number of subjects with causal mutations. In transgenic rabbits that fully recapitulate the FHCM phenotype, reduced myocardial tissue Doppler (TD) velocities accurately identified the mutant rabbits, even in the absence of LVH. We tested whether humans with FHCM also consistently showed reduced myocardial TD velocities, irrespective of LVH. METHODS AND RESULTS: We performed 2D and Doppler echocardiography and TD imaging in 30 subjects with FHCM, 13 subjects who were positive for various mutations but did not have LVH, and 30 age- and sex-matched controls (all adults; 77% women). LV wall thickness and mass were significantly greater in FHCM subjects (P<0.01 versus those without LVH and controls). There were no significant differences in 2D echocardiographic, mitral, and pulmonary venous flow indices between mutation-positives without LVH and controls. In contrast, systolic and early diastolic TD velocities were significantly lower in both mutation-positives without LVH and in FHCM patients than in controls (P<0.001). Reduced TD velocities had a sensitivity of 100% and a specificity of 93% for identifying mutation-positives without LVH. CONCLUSIONS: Myocardial contraction and relaxation velocities, detected by TD imaging, are reduced in FHCM, including in those without LVH. Before and independently of LVH, TD imaging is an accurate and sensitive method for identifying subjects who are positive for FHCM mutations. |
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Authors:
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S F Nagueh; L L Bachinski; D Meyer; R Hill; W A Zoghbi; J W Tam; M A Quiñones; R Roberts; A J Marian |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 104 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-07-11 Completed Date: 2001-08-09 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 128-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, TX, USA. sherifn@bcm.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity / genetics Cardiomyopathy, Hypertrophic / complications, diagnosis*, genetics* Diastole Echocardiography* Echocardiography, Doppler* Female Genes, Dominant Genetic Predisposition to Disease Humans Hypertrophy, Left Ventricular / diagnosis*, etiology Male Mutation Predictive Value of Tests Sensitivity and Specificity Systole Ventricular Function, Left / genetics |
| Grant Support | |
ID/Acronym/Agency:
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P50 HL054313-060012/HL/NHLBI NIH HHS; P50 HL054313-070012/HL/NHLBI NIH HHS; P50 HL054313-080012/HL/NHLBI NIH HHS; P50 HL054313-08S10012/HL/NHLBI NIH HHS; P50 HL054313-090012/HL/NHLBI NIH HHS; P50 HL054313-100012/HL/NHLBI NIH HHS; P50-HL42267-01/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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Circulation. 2001 Jul 10;104(2):126-7
[PMID:
11447071
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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