Document Detail

Tissue Doppler echocardiography improves the diagnosis of coronary artery stenosis in stable angina pectoris.
MedLine Citation:
PMID:  22323549     Owner:  NLM     Status:  MEDLINE    
METHODS AND RESULTS: This study comprises 296 consecutive patients with clinically suspected SAP, no previous cardiac history, and a normal ejection fraction. All patients were examined by colour TDI, exercise electrocardiogram (ECG), and coronary angiography (CAG). Regional longitudinal systolic (s'), early diastolic (e'), and late diastolic (a') myocardial velocities were measured by colour TDI at six mitral annular sites and averaged to provide global estimates. Duke score (DS), including ST depression, chest pain, and exercise capacity, was used as the outcome of the exercise ECG. Patients with an area stenosis of ≥70% in at least one epicardial coronary artery were categorized as having a significant CAD (n= 108) and were compared with patients without significant CAD (n= 188). Both e' [odds ratio (OR): 1.5 (1.1-1.9, P < 0.01) per cm/s decrease] and s' [OR: 1.7 (1.1-2.5, P < 0.05) per cm/s decrease] remained independent predictors of CAD after multivariable adjustment for baseline, exercise ECG, and conventional echocardiographic parameters. Area under the receiver operating characteristic curve (AUC) for exercise ECG and TDI in combination was significantly higher than AUC for exercise ECG alone (0.84 vs. 0.79, P < 0.01).
CONCLUSION: In patients with suspected SAP colour TDI performed at rest is an independent predictor of significant CAD, and colour TDI improves the diagnostic performance of exercise ECG.
Soren Hoffmann; Jan Skov Jensen; Allan Zeeberg Iversen; Peter Sogaard; Soren Galatius; Niels Thue Olsen; Jan Bech; Thomas Fritz-Hansen; Tor Biering-Sorensen; Jorn Badskjaer; Adrian Pietersen; Rasmus Mogelvang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-08
Journal Detail:
Title:  European heart journal cardiovascular Imaging     Volume:  13     ISSN:  2047-2412     ISO Abbreviation:  Eur Heart J Cardiovasc Imaging     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-09     Completed Date:  2013-01-07     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  101573788     Medline TA:  Eur Heart J Cardiovasc Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  724-9     Citation Subset:  IM    
Department of Cardiology, Gentofte University Hospital, Post 4210, 65 Niels Andersens Vej, DK-2900 Hellerup, Copenhagen, Denmark.
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MeSH Terms
Angina, Stable / ultrasonography*
Chi-Square Distribution
Coronary Angiography
Coronary Stenosis / ultrasonography*
Echocardiography, Doppler, Color / methods
Exercise Test
Logistic Models
Middle Aged
Predictive Value of Tests
ROC Curve

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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