Document Detail


Tissue Doppler and Strain Rate Imaging Detect Improvement of Myocardial Function in Iron Deficient Patients with Congestive Heart Failure after Iron Replacement Therapy.
MedLine Citation:
PMID:  22050368     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Iron deficiency may contribute to diminished exercise tolerance in patients with congestive heart failure (CHF) even in absence of anemia. The aim of this study was to evaluate the effect of correction of iron deficiency on functional capacity and myocardial function in patients with CHF. Methods: We studied 40 patients with ejection fraction <40%, hemoglobin% >12 g/dL, serum ferritin <100 ug/L, and transferrin saturation <20%. Patients received 200 mg weekly doses of iron dextran complex until serum ferritin level was between 200 and 300 ug/L or transferrin saturation level was between 30% and 40%. Transthoracic echocardiogram, tissue Doppler imaging, peak systolic strain rate, and 6 minute walk test were performed before iron therapy and at 12-week follow up. Peak early diastolic myocardial tissue velocity (E'), peak late diastolic myocardial tissue velocity (A'), and peak systolic myocardial tissue velocity (S') were measured. Results: There was a significant improvement of New York Heart Association functional class (3.0 ± 0.4 vs. 2.1 ± 0.3, P < 0.05) and 6minutes walk distance (322 ± 104 vs. 377 ± 76, P < 0.01) from rest to follow up, respectively. Ejection fraction did not change significantly (32 ± 8% vs. 34 ± 9%, respectively). There was a significant improvement of S'-wave (3.0 ± 0.8 cm/sec vs. 6.0 ± 1.2 cm/sec, P < 0.05), E/E' ratio (22 ± 3 vs. 13 ± 3, P < 0.05), and peak systolic strain rate (-0.72 ± 0.11/s vs. -1.09 ± 0.37/s, P < 0.05) from baseline to follow-up, respectively. Conclusion: Correction of iron deficiency improves functional class and walking distance in nonanemic iron deficient patients with systolic heart failure. Tissue Doppler and strain rate demonstrated a significant improvement of diastolic and systolic function after therapy despite lack of improvement of ejection fraction. (Echocardiography ****;**:1-6).
Authors:
Rania Gaber; Nesreen A Kotb; Medhat Ghazy; Hala M Nagy; Mai Salama; Abdou Elhendy
Related Documents :
9434088 - Sympathetic denervation of myocardium demonstrated by 123i-mibg scintigraphy in pure pr...
16624588 - Strategies for improving the detection of fmri activation in trigeminal pathways with c...
1942498 - Relation of change in wall motion and glucose metabolism after coronary artery bypass g...
14516528 - Determination of myocardial viability with ecg-gated fluorodeoxyglucose f-18 positron e...
8463008 - Atrio-ventricular regurgitations in constrictive pericarditis: incidence and post-opera...
8873958 - Ischemic heart disease in chronic uremia.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-2
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  -     ISSN:  1540-8175     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011, Wiley Periodicals, Inc.
Affiliation:
Departments of Cardiology Department of Internal Medicine Department of Clinical Pathology, Tanta University, Tanta, Egypt Department of Cardiology, Marshfield Clinic, Marshfield, Wisconsin.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Systems-wide Proteomic Analysis in Mammalian Cells Reveals Conserved, Functional Protein Turnover.
Next Document:  Pentanuclear Cyanide-Bridged Complexes Based on Highly Anisotropic Co(II) Seven-Coordinate Building ...