| Tissue Doppler imaging of right ventricular decompensation in pulmonary hypertension. | |
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MedLine Citation:
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PMID: 19925505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Right ventricular (RV) function is closely linked to outcomes in pulmonary hypertension (PH). The authors sought to evaluate RV myocardial strain in 3 groups of patients: normal, PH with compensated RV function (PH-C), and PH with decompensated RV function (PH-D). Fifty-six patients (aged 56+/-12 years; 40 women; mean pulmonary artery pressure [MPAP] range, 13-82 mm Hg) underwent right heart catheterization and 2-dimensional echocardiography with tissue Doppler imaging of the RV. Right atrial pressures were 6+/-3, 5+/-2, and 14+/-4 mm Hg; MPAP values were 19+/-3, 44+/-15, and 56+/-13 mm Hg; pulmonary vascular resistances were 1.4+/-0.4, 7.9+/-5.1, and 11.5+/-6.6 Wood units; and cardiac indices were 3.4+/-0.9, 2.8+/-0.8, and 2.2+/-0.7 L/min/m(2) (P<.05 for all for normal, PH-C, and PH-D patients), respectively. RV free wall strain decreased significantly among all 3 groups (-26%+/-6%, -19%+/-7%, and -14%+/-5%; P<.0001). RV free wall strain decreases in PH without hemodynamically decompensated RV function suggesting it may be a preceding step in the development of RV failure. This may be of particular use in following patients sequentially. |
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Authors:
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Marc A Simon; Navin Rajagopalan; Michael A Mathier; Sanjeev G Shroff; Michael R Pinsky; Angel López-Candales |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Congestive heart failure (Greenwich, Conn.) Volume: 15 ISSN: 1751-7133 ISO Abbreviation: Congest Heart Fail Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-03-29 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9714174 Medline TA: Congest Heart Fail Country: United States |
Other Details:
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Languages: eng Pagination: 271-6 Citation Subset: IM |
Affiliation:
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Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA. simonma@upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Echocardiography, Doppler* Female Health Status Indicators Heart Failure / complications, ultrasonography* Heart Ventricles / pathology, ultrasonography Hemodynamics Humans Hypertension, Pulmonary / complications* Male Middle Aged ROC Curve Reproducibility of Results Statistics as Topic Ventricular Dysfunction, Right / complications, ultrasonography* Ventricular Function, Left |
| Grant Support | |
ID/Acronym/Agency:
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HL067181/HL/NHLBI NIH HHS; HL07820/HL/NHLBI NIH HHS; K24 HL067181-07/HL/NHLBI NIH HHS; KL2 RR024154/RR/NCRR NIH HHS; L30 HL078435-03A1/HL/NHLBI NIH HHS; T32 HL007820-04/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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