Document Detail

Tissue Doppler Imaging Dyssynchrony Parameter Derived From the Myocardial Active Wall Motion Improves Prediction of Responders for Cardiac Resynchronization Therapy.
MedLine Citation:
PMID:  22240595     Owner:  NLM     Status:  Publisher    
Background: The aim of this study was to propose modified tissue Doppler imaging (TDI) parameters derived from the first active wall motion and to assess them for the better prediction of cardiac resynchronization therapy (CRT) responders in comparison with to original TDI parameters. Methods and Results: In 61 patients with CRT, time from QRS onset to peak velocities by TDI (Ts), which were derived from active wall motion identified by longitudinal strain rate (LSR) value, were assessed. Time from QRS onset to the negative peak of LSR (TLSR) was also assessed. Modified standard deviation of Ts in 12 left ventricular (LV) segments (Ts-SD), that of TLSR (TLSR-SD), differences of Ts between septum and lateral wall (Ts-SL), and that of TLSR (TLSR-SL) were calculated. Original Ts-SD and Ts-SL were calculated by previously described methods. Responders were defined as patients with LV end-systolic volume reduction (>15%) at 6 months after CRT: 35 patients (57%) were identified as CRT responders. Area under the receiver-operating characteristics curve (AUC) of modified Ts-SD (0.87) was significantly higher than that of Ts-SD (0.65), Ts-SL (0.62), and TLSR-SL (0.69). AUC of modified Ts-SL was significantly higher than those of Ts-SD, and Ts-SL. AUC of TLSR-SD (0.82) also was significantly higher than that of Ts-SD. Conclusions: Modified TDI dyssynchrony parameters derived from the first active wall motion improve the ability to predict responders to CRT.
Fumiko Sakamaki; Yoshihiro Seo; Tomoko Ishizu; Satomi Yanaka; Akiko Atsumi; Masayoshi Yamamoto; Tomoko Machino-Ohtsuka; Ryo Kawamura; Hiro Yamasaki; Miyako Igarashi; Kentaro Yoshida; Yukio Sekiguchi; Hiroshi Tada; Kazutaka Aonuma
Related Documents :
22361405 - Cardiac-specific deletion of socs-3 prevents development of left ventricular remodeling...
22580715 - Pacing polarity and left ventricular mechanical activation sequence in cardiac resynchr...
21739365 - Role of various proteases in cardiac remodeling and progression of heart failure.
22825905 - Characteristics of systolic and diastolic potentials recorded in the left interventricu...
24721545 - Epac contributes to cardiac hypertrophy and amyloidosis induced by radiotherapy but not...
23392955 - Posteroseptal accessory pathway in association with coronary sinus diverticulum: electr...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-13
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  -     ISSN:  1347-4820     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Clinical Laboratory, Tsukuba University Hospital.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Left Ventricular Mechanical Dyssynchrony Impairs Exercise Capacity in Patients With Coronary Artery ...
Next Document:  Hemodialysis-Induced P-Wave Signal-Averaged Electrocardiogram Alterations Are Indicative of Vulnerab...