| Tissue characterization of coronary plaques and assessment of thickness of fibrous cap using integrated backscatter intravascular ultrasound. Comparison with histology and optical coherence tomography. | |
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MedLine Citation:
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PMID: 20953061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The purpose of this study was to develop a new online integrated backscatter intravascular ultrasound (IB-IVUS) system and to validate its ability to measure fibrous cap thickness by comparing IB-IVUS images with those from optical coherence tomography (OCT). METHODS AND RESULTS: Images were acquired from 125 segments of 26 coronary arteries obtained at autopsy from 11 cadavers. In the training study (n=30), 242 regions-of-interest on color-coded maps were compared with histology. In the validation study, 95 cross-sections were diagnosed by IB-IVUS and histology. In 24 patients with stable angina, 28 arterial cross-sections were imaged by IB-IVUS and OCT in vivo. In the training study, cutoff values of 39 decibels (dB) and 17dB were the optimal predictors of lipid pool/fibrosis and fibrosis/calcification, respectively, with 38-MHz mode; 42dB and 20dB, respectively, with 43-MHz mode. In the validation study, IB classified the fibrous, lipid-rich and fibrocalcific components with an accuracy of 92%, 91% and 95%, respectively. Agreement between the histological and IB-IVUS diagnoses was excellent (Cohen's κ=0.83). There was a correlation between the fibrous cap thickness measured by IB-IVUS and OCT (r=0.74, P<0.001). CONCLUSIONS: The IB-IVUS system with improved resolution provides high diagnostic accuracy for the analysis of the tissue characteristics of coronary plaques, and enables estimation of the thickness of the fibrous cap in the clinical setting. |
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Authors:
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Masanori Kawasaki; Arihiro Hattori; Yoshiyuki Ishihara; Munenori Okubo; Kazuhiko Nishigaki; Genzou Takemura; Masanao Saio; Tsuyoshi Takami; Shinya Minatoguchi |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-09 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-12-02 Completed Date: 2011-03-09 Revised Date: 2012-01-09 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 2641-8 Citation Subset: IM |
Affiliation:
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Regeneration & Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan. masanori@ya2.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris
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pathology* Calcinosis / pathology* Female Humans Male Tomography, Optical Coherence / methods* Ultrasonography, Interventional / methods* |
| Comments/Corrections | |
Comment In:
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Circ J. 2010 Nov;74(12):2554-5
[PMID:
21088332
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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