| Tips, Stalks, Tubes: Notch-Mediated Cell Fate Determination and Mechanisms of Tubulogenesis during Angiogenesis. | |
| | |
MedLine Citation:
|
PMID: 22355796 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Angiogenesis is the process of developing vascular sprouts from existing blood vessels. Luminal endothelial cells convert into "tip" cells that contribute to the development of a multicellular stalk, which then undergoes lumen formation. In this review, we consider a variety of cellular and molecular pathways that mediate these transitions. We focus first on Notch signaling in cell fate determination as a mechanism to define tip and stalk cells. We next discuss the current models of lumen formation and describe new players in this process, such as chloride intracellular channel proteins. Finally, we consider the possible medical therapeutic benefits of understanding these processes and acknowledge potential obstacles in drug development. |
| | |
Authors:
|
Jennifer J Tung; Ian W Tattersall; Jan Kitajewski |
Related Documents
:
|
16997326 - Ameboid cell motility: a model and inverse problem, with an application to live cell im... 22350846 - Endogenous voltage gradients as mediators of cell-cell communication: strategies for in... 7450056 - Dynamics of the biological response to molecular injury: a mathematical model. 8703416 - Patterns of spontaneous motility in videomicrographs of human epidermal keratinocytes (... 12615706 - Delayed reactivation of p53 in the progeny of cells surviving ionizing radiation. 18549516 - Langerhans' cell histiocytosis of the temporal bone: successful treatment of sensorineu... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cold Spring Harbor perspectives in medicine Volume: 2 ISSN: 2157-1422 ISO Abbreviation: Cold Spring Harb Perspect Med Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-02-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101571139 Medline TA: Cold Spring Harb Perspect Med Country: United States |
Other Details:
|
Languages: eng Pagination: a006601 Citation Subset: - |
Affiliation:
|
Department of Obstetrics/Gynecology and Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vascular hyperpermeability, angiogenesis, and stroma generation.
Next Document: Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression.