Document Detail


Tips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesis.
MedLine Citation:
PMID:  22355796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiogenesis is the process of developing vascular sprouts from existing blood vessels. Luminal endothelial cells convert into "tip" cells that contribute to the development of a multicellular stalk, which then undergoes lumen formation. In this review, we consider a variety of cellular and molecular pathways that mediate these transitions. We focus first on Notch signaling in cell fate determination as a mechanism to define tip and stalk cells. We next discuss the current models of lumen formation and describe new players in this process, such as chloride intracellular channel proteins. Finally, we consider the possible medical therapeutic benefits of understanding these processes and acknowledge potential obstacles in drug development.
Authors:
Jennifer J Tung; Ian W Tattersall; Jan Kitajewski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Cold Spring Harbor perspectives in medicine     Volume:  2     ISSN:  2157-1422     ISO Abbreviation:  Cold Spring Harb Perspect Med     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-22     Completed Date:  2013-06-17     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101571139     Medline TA:  Cold Spring Harb Perspect Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  a006601     Citation Subset:  IM    
Affiliation:
Department of Obstetrics/Gynecology and Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / therapeutic use
Chloride Channels / physiology
Drug Design
Humans
Neoplasms / blood supply*,  drug therapy
Neovascularization, Pathologic / physiopathology*
Neovascularization, Physiologic / physiology*
Receptors, Notch / antagonists & inhibitors,  physiology*
Signal Transduction / physiology*
Vascular Endothelial Growth Factor A / physiology
Grant Support
ID/Acronym/Agency:
2T32 CA09503/CA/NCI NIH HHS; 5R01 HL062454/HL/NHLBI NIH HHS; T32-GM07367/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Chloride Channels; 0/Receptors, Notch; 0/Vascular Endothelial Growth Factor A
Comments/Corrections

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