Document Detail

Tinidazole and metronidazole in hepatic amoebiasis.
MedLine Citation:
PMID:  350565     Owner:  NLM     Status:  MEDLINE    
The efficacy of metronidazole and tinidazole has been compared in 31 patients with hepatic amoebiasis. Only those with unequivocal clinical, radiological and laboratory evidence of hepatic amoebiasis were included; diagnostic and therapeutic aspiration was performed where necessary. 15 patients received metronidazole and 16 tinidazole, in random order. The 2 groups were comparable. Both drugs were given orally in a single daily dose of 2g for a minimum of 3 days, with treatment extended if considered clinically advisable. 12 of 15 patients (80%) were cured with metronidazole given for an average period of 7 days (range 4 to 14 days). 15 of 16 patients (93.8%) given tinidazole were cured and the mean duration of treatment was 4 days (range 3 to 6 days). There were fewer side-effects with tinidazole. In this study of hepatic amoebiasis in Bangladesh, tinidazole was found to be superior to metronidazole in overall efficacy because a shorter course of treatment was necessary and it caused fewer side-effects.
N Islam; K Hasan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Drugs     Volume:  15 Suppl 1     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1978  
Date Detail:
Created Date:  1978-08-28     Completed Date:  1978-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  26-9     Citation Subset:  IM    
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MeSH Terms
Age Factors
Clinical Trials as Topic
Liver Abscess, Amebic / drug therapy*
Metronidazole / adverse effects,  therapeutic use*
Middle Aged
Nitroimidazoles / therapeutic use*
Tinidazole / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Nitroimidazoles; 19387-91-8/Tinidazole; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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