Document Detail


Tin-metalloporphyrins: an answer to neonatal jaundice?
MedLine Citation:
PMID:  9791442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperbilirubinemia is a common problem, affecting 45-60 percent of term infants and up to 80 percent of premature neonates. Phototherapy, the standard treatment for neonatal hyperbilirubinemia, is effective but has the potential for adverse effects. Prevention of bilirubin formation, rather than dependence on therapeutic measures to remove excess bile pigment, is a logical alternative. Metalloporphyrins--specifically tin-protoporphyrin (SnPP) and tin-mesoporphyrin (SnMP)--are being used experimentally to prevent and treat neonatal hyperbilirubinemia. This article reports the findings of studies exploring the use of SnPP and SnMP.
Authors:
S Steffensrud
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neonatal network : NN     Volume:  17     ISSN:  0730-0832     ISO Abbreviation:  Neonatal Netw     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1999-04-29     Completed Date:  1999-04-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8503921     Medline TA:  Neonatal Netw     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-7; quiz 18-9     Citation Subset:  N    
Affiliation:
Medical University of South Carolina, Charleston, USA.
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MeSH Terms
Descriptor/Qualifier:
Heme Oxygenase (Decyclizing) / antagonists & inhibitors*
Humans
Infant, Newborn
Jaundice, Neonatal / drug therapy*,  etiology,  nursing
Metalloporphyrins / pharmacology,  therapeutic use*
Neonatal Nursing
Phototherapy / adverse effects
Chemical
Reg. No./Substance:
0/Metalloporphyrins; 106344-20-1/tin mesoporphyrin; EC 1.14.99.3/Heme Oxygenase (Decyclizing)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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