Document Detail


Tin mesoporphyrin in conjunction with retinoic acid reverses the retinoic acid induced enhancement of phospholipase A(2) activity in vivo in rats.
MedLine Citation:
PMID:  17573627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retinol (Vitamin A) is known to destabilize membranes. The effect of one of its natural derivatives, Retinoic Acid, was therefore studied on membrane stability, by inversely correlating this stability with Phospholipase A(2) activity. Lipid metalloporphyrin interactions have been the object of intense research in recent times. Our results revealed that the administration of Retinoic Acid (50,000 I.U.) caused a tremendous induction of hepatic Phospholipase A(2) activity in Wistar rats. However when Retinoic Acid and Tin-mesoporphyrin (50 micromol/kgbw) were co-administered, hepatic Phospholipase A(2) activity was inhibited. This result clearly reveals a possible therapeutic application of this metalloporphyrin in alleviating membrane destabilization, connected with Retinoic acid administration.
Authors:
Manisha Tiwari; Ramesh Chandra; Sujata K Das; Satya Prakash
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  35     ISSN:  1073-1199     ISO Abbreviation:  Artif Cells Blood Substit Immobil Biotechnol     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-18     Completed Date:  2007-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  275-85     Citation Subset:  IM    
Affiliation:
Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / metabolism
Cell Membrane Permeability / drug effects*
Enzyme Inhibitors / pharmacology
Liver / enzymology*
Membrane Proteins / analysis,  metabolism*
Metalloporphyrins / pharmacology*
Molecular Structure
Phospholipases A / drug effects*,  metabolism
Rats
Rats, Wistar
Tretinoin / pharmacology*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Membrane Proteins; 0/Metalloporphyrins; 106344-20-1/tin mesoporphyrin; 302-79-4/Tretinoin; EC 3.1.1.-/Phospholipases A

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