Document Detail


Tin oxide nanowires suppress herpes simplex virus-1 entry and cell-to-cell membrane fusion.
MedLine Citation:
PMID:  23110193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The advent of nanotechnology has ushered in the use of modified nanoparticles as potential antiviral agents against diseases such as herpes simplex virus 1 and 2 (HSV-1) (HSV-2), human immunodeficiency virus (HIV), monkeypox virus, and hepatitis B virus. Here we describe the application of tin oxide (SnO(2)) nanowires as an effective treatment against HSV-1 infection. SnO(2) nanowires work as a carrier of negatively charged structures that compete with HSV-1 attachment to cell bound heparan sulfate (HS), therefore inhibiting entry and subsequent cell-to-cell spread. This promising new approach can be developed into a novel form of broad-spectrum antiviral therapy especially since HS has been shown to serve as a cellular co-receptor for a number of other viruses as well, including the respiratory syncytial virus, adeno-associated virus type 2, and human papilloma virus.
Authors:
James Trigilio; Thessicar E Antoine; Ingo Paulowicz; Yogendra K Mishra; Rainer Adelung; Deepak Shukla
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-24
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-30     Completed Date:  2013-04-26     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e48147     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology & Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / chemistry,  pharmacology
Cell Line
Heparitin Sulfate / chemistry
Herpes Simplex / prevention & control*
Herpesvirus 1, Human / drug effects,  pathogenicity*
Herpesvirus 2, Human / drug effects,  pathogenicity
Humans
Membrane Fusion / drug effects*
Nanowires / chemistry*,  therapeutic use*
Tin Compounds / chemistry,  pharmacology*
Grant Support
ID/Acronym/Agency:
AI081869/AI/NIAID NIH HHS; R01 AI057860/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Tin Compounds; 18282-10-5/stannic oxide; 9050-30-0/Heparitin Sulfate
Comments/Corrections

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