Document Detail

Timoptol--three years on. A study of timolol maleate drops over a longer period.
MedLine Citation:
PMID:  6639506     Owner:  NLM     Status:  MEDLINE    
A group of 130 patients with chronic glaucoma has been followed from one to more than three years on timolol maleate drops; this confirms that these drops remain effective in long-term therapy through added therapy is usually needed. Of 54 patients originally controlled by timolol alone or in combination, only four were not controlled more than three years later, though some needed further additional therapy. Of 35 patients followed for two to three years, only six could not be controlled by timolol alone or in combination; and of 41 followed for one to two years, 18 were controlled on timolol alone while 23 needed additional therapy. Attention is drawn to side effects including a mild keratopathy and in particular the occurrence of bronchospasm or other severe respiratory disease in 10 patients, not all of whom had a previous history of respiratory disease. Great care should be exercised with timolol in the presence of present or past respiratory disease as the complication is not generally recognised and it falls to the ophthalmologist to act to stop the drop.
W E Gillies; R H West; L Cebon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian journal of ophthalmology     Volume:  11     ISSN:  0310-1177     ISO Abbreviation:  Aust J Ophthalmol     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365543     Medline TA:  Aust J Ophthalmol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  155-7     Citation Subset:  IM    
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MeSH Terms
Drug Therapy, Combination
Follow-Up Studies
Glaucoma / drug therapy*
Ophthalmic Solutions
Respiratory Tract Diseases / chemically induced
Timolol / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Ophthalmic Solutions; 26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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