Document Detail

Timolol gel versus acetazolamide in the prophylaxis of ocular hypertension after phacoemulsification.
MedLine Citation:
PMID:  9379379     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare postoperative intraocular pressure (IOP) after administration of acetazolamide and timolol following phacoemulsification and intraocular lens implantation. SETTING: Ophthalmic Consultants of Long Island, Rockville Centre, New York, USA. METHODS: Sixty patients were included in a prospective, randomized, masked trial. The patients received either two doses of oral, sustained-release acetazolamide (Diamox Sequels) or a single dose of topical timolol 0.5% gel (Timoptic XE). Intraocular pressure was measured by Goldmann applanation tonometry preoperatively and 1 day postoperatively. RESULTS: Mean preoperative IOP was 16.4 mm Hg. One day postoperatively, it was 19.5 mm Hg in the oral acetazolamide group and 15.9 mm Hg in the timolol gel group. One patient in the acetazolamide group developed significant adverse reactions. CONCLUSION: Prophylactic use of topical timolol 0.5% gel for viscoelastic-induced ocular hypertension after cataract extraction appears to offer better IOP control than oral acetazolamide and has potentially fewer adverse systemic effects.
A J Kanellopoulos; H D Perry; E D Donnenfeld
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  23     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-12     Completed Date:  1997-11-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1070-4     Citation Subset:  IM    
Department of Ophthalmology, State University of New York, Health Science Center at Brooklyn 11203, USA.
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MeSH Terms
Acetazolamide / administration & dosage,  adverse effects,  therapeutic use*
Adrenergic beta-Antagonists / administration & dosage,  adverse effects,  therapeutic use*
Carbonic Anhydrase Inhibitors / administration & dosage,  adverse effects,  therapeutic use*
Delayed-Action Preparations
Double-Blind Method
Intraocular Pressure
Lens Implantation, Intraocular
Ocular Hypertension / etiology,  prevention & control*
Phacoemulsification / adverse effects*
Prospective Studies
Timolol / administration & dosage,  adverse effects,  therapeutic use*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbonic Anhydrase Inhibitors; 0/Delayed-Action Preparations; 0/Gels; 26839-75-8/Timolol; 59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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