| Timing of yawns induced by a small dose of apomorphine and its alteration by naloxone. | |
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MedLine Citation:
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PMID: 6531446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The report examines the temporal sequence of yawns induced by apomorphine and whether the opiate antagonist, naloxone, affects it. Before administering apomorphine (0.075 mg/kg) or saline, rats (n = 8) were pretreated with naloxone (1 mg/kg) or saline. Each subject received all 4 possible treatments (saline-saline, saline-apomorphine, naloxone-saline, and naloxone-apomorphine) in random order. Results indicate that yawning induced by apomorphine seems to come in fits; that is, there is a series of yawns spaced closely together and followed by a period of quiescence before the start of another cluster of yawns. Naloxone reduced the number of apomorphine-induced yawns, and the occurrence of very short inter-yawn intervals. It is suggested that the timing of yawns may provide useful information regarding some pathologies and that opiates may potentiate the action of dopaminergic systems. |
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Authors:
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H Szechtman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 8 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 1984 |
Date Detail:
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Created Date: 1985-05-17 Completed Date: 1985-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 743-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apomorphine / antagonists & inhibitors, pharmacology* Male Naloxone / pharmacology* Rats Rats, Inbred Strains Reflex / drug effects* Respiration / drug effects |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone; 58-00-4/Apomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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