Document Detail


Timing of vaccinations in premature infants.
MedLine Citation:
PMID:  18034540     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Preterm infants have immunological immaturities that may impact on vaccine responses. Larger premature infants mount immune responses to vaccines that are similar to those of full term infants, but very premature infants (<30 weeks' gestation at birth) have specific defects in vaccine responsiveness. The immunogenicity of diphtheria, tetanus and pertussis antigens is similar in full term and premature infants. Poliovirus vaccines, however, do not always stimulate adequate antibody responses in premature infants. The immunogenicity of Haemophilus influenzae type b conjugate vaccines varies widely in studies of premature infants, and may be affected both by choice of conjugate protein and by the infant's overall health. Hepatitis B vaccine given at birth appears poorly immunogenic in infants with birthweights <1750g, with delay in the administration of the first dose yielding improved immunogenicity. Sick premature infants may suffer increased episodes of apnoea following vaccine administration. Persistence of immunity, the quality of the immune response, and evaluation of the specific tolerability and immunogenicity of new vaccines in premature infants are topics needing further research. Although it is generally true that recommendations for vaccination of term infants are applicable to premature infants, it is not always specifically true. Optimal care of preterm infants requires attention to the exceptions to this generalisation.
Authors:
C T Dangio; C B Hall
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy     Volume:  13     ISSN:  1173-8804     ISO Abbreviation:  BioDrugs     Publication Date:  2000 May 
Date Detail:
Created Date:  2007-11-23     Completed Date:  2009-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705305     Medline TA:  BioDrugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  335-46     Citation Subset:  -    
Affiliation:
Department of Paediatrics, University of Rochester School of Medicine and Dentistry, Strong Children's Research Center, Rochester, New York 14642, USA. carl_dangio@urmc.rochester.edu
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