Document Detail


Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke.
MedLine Citation:
PMID:  10926939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The duration of cerebral blood flow impairment correlates with irreversibility of brain damage in animal models of cerebral ischemia. Our aim was to correlate clinical recovery from stroke with the timing of arterial recanalization after therapy with intravenous tissue plasminogen activator (tPA). METHODS: Patients with symptoms of cerebral ischemia were treated with 0.9 mg/kg tPA IV within 3 hours after stroke onset (standard protocol) or with 0.6 mg/kg at 3 to 6 hours (an experimental institutional review board-approved protocol). National Institutes of Health Stroke Scale (NIHSS) scores were obtained before treatment, at the end of tPA infusion, and at 24 hours; Rankin Scores were obtained at long-term follow-up. Transcranial Doppler (TCD) was used to locate arterial occlusion before tPA and to monitor recanalization (Marc head frame, Spencer Technologies; Multigon 500M, DWL MultiDop-T). Recanalization on TCD was determined according to previously developed criteria. RESULTS: Forty patients were studied (age 70+/-16 years, baseline NIHSS score 18.6+/-6.2). A tPA bolus was administered at 132+/-54 minutes from symptom onset. Recanalization on TCD was found at the mean time of 251+/-171 minutes after stroke onset: complete recanalization occurred in 12 (30%) patients and partial recanalization occurred in 16 (40%) patients (maximum observation time 360 minutes). Recanalization occurred within 60 minutes of tPA bolus in 75% of patients who recanalized. The timing of recanalization inversely correlated with early improvement in the NIHSS scores within the next hour (polynomial curve, third order r(2)=0.429, P<0.01) as well as at 24 hours. Complete recanalization was common in patients who had follow-up Rankin Scores if 0 to 1 (P=0.006). No patients had early complete recovery if an occlusion persisted for >300 minutes. CONCLUSIONS: The timing of arterial recanalization after tPA therapy as determined with TCD correlates with clinical recovery from stroke and demonstrates a 300-minute window to achieve early complete recovery. These data parallel findings in animal models of cerebral ischemia and confirm the relevance of these models in the prediction of response to reperfusion therapy.
Authors:
I Christou; A V Alexandrov; W S Burgin; A W Wojner; R A Felberg; M Malkoff; J C Grotta
Related Documents :
6276069 - The effect of carotid endarterectomy on mental functioning.
24760379 - Nutritional improvement following growing rod surgery in children with early onset scol...
2730179 - Recurrent carotid artery stenosis. resection with autogenous vein replacement.
17199089 - Acute stroke management in the elderly.
15706559 - Late motor recovery is influenced by muscle tone changes after stroke.
23945509 - Novel parameters reflect changes in morphology of respiratory events during weight loss.
25174939 - Biceps tenodesis for long head of the biceps after auto-rupture or failed surgical teno...
20021539 - Efficacy of combination drug pulse therapy in maintaining lipid levels in patients into...
6949549 - Results of geometric arthroplasty for rheumatoid and osteoarthritis of the knee.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  31     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-08-29     Completed Date:  2000-08-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1812-6     Citation Subset:  IM    
Affiliation:
Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas-Houston Medical School, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Blood Flow Velocity / drug effects
Brain Ischemia / drug therapy,  physiopathology*,  ultrasonography
Cerebral Arteries / ultrasonography*
Cerebrovascular Circulation / drug effects,  physiology*
Female
Follow-Up Studies
Humans
Injections, Intravenous
Male
Monitoring, Physiologic / methods
Plasminogen Activators / administration & dosage*
Prospective Studies
Recovery of Function* / drug effects
Reproducibility of Results
Time Factors
Tissue Plasminogen Activator / administration & dosage*
Ultrasonography, Doppler, Transcranial*
Grant Support
ID/Acronym/Agency:
1-T32-NS07412-O1A1/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intracranial hemorrhage associated with thrombolytic therapy for elderly patients with acute myocard...
Next Document:  Association of intraoperative transcranial doppler monitoring variables with stroke from carotid end...