Document Detail

Timing of presentation and postnatal outcome of infants suspected of having coarctation of the aorta during fetal life.
MedLine Citation:
PMID:  16020599     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report the timing of presentation and clinical profile of a cohort of fetuses with normal main cardiac connections but fetal echocardiographic signs suggestive of coarctation of the aorta. DESIGN: Retrospective observational study. SETTING: Tertiary fetal and paediatric cardiology centre. PATIENTS: Between 1 January 1998 and 31 December 2002, 174 fetuses were studied, of whom 144 infants were born alive. MAIN OUTCOME MEASURES: Of the 144 liveborn infants, 43 had coarctation of the aorta, four had interruption of the aortic arch, and one was managed as having hypoplastic left heart syndrome. Hemianomalous pulmonary venous drainage was diagnosed in two infants. Three infants with coarctation presented late at 7-13 weeks of age, 6-12 weeks after closure of the arterial duct. Fetuses with cardiac asymmetry had a higher incidence of left superior vena cava than a control group. For fetuses with cardiac asymmetry, the incidence of left superior vena cava and ventricular septal defects was similar in infants who proved to have coarctation postnatally and in those who did not. The 30 day and one year surgical mortality of infants having repair of coarctation of the aorta was two of 41 (4.9%, 95% confidence interval (CI) 0.6 to 16.0). All cause mortality of liveborn infants with any abnormality of the aortic arch was five of 48 (10.4%, 95% CI 3.5 to 22.7) at 30 days and one year, which was heavily influenced by prematurity and extracardiac abnormalities. CONCLUSIONS: Precise diagnosis of coarctation of the aorta during fetal life remains difficult. Coarctation of the aorta may present several weeks after closure of the arterial duct and sequential echocardiography is recommended.
C E G Head; V C Jowett; G K Sharland; J M Simpson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  91     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-15     Completed Date:  2005-08-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1070-4     Citation Subset:  AIM; IM    
Department of Cardiology, University Hospital, Birmingham, UK.
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MeSH Terms
Aortic Coarctation / embryology,  pathology,  ultrasonography*
Echocardiography / methods*
Fetal Diseases / pathology,  ultrasonography*
Pregnancy Outcome
Retrospective Studies
Time Factors
Ultrasonography, Prenatal / methods*

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