Document Detail

Timing of operation for chronic aortic regurgitation.
MedLine Citation:
PMID:  7048887     Owner:  NLM     Status:  MEDLINE    
Left ventricular systolic function is an important determinant of long-term prognosis in patients with chronic aortic regurgitation. Data from several centers, using invasive and noninvasive assessment of left ventricular function, indicate that long-term postoperative survival is excellent, even in symptomatic patients, if preoperative left ventricular systolic function is normal. The long-term postoperative results are significantly worse in symptomatic patients with preoperative left ventricular systolic dysfunction, many of whom appear to have irreversible left ventricular failure before the onset of symptoms and are at a risk of late postoperative death from congestive heart failure. However, within this high risk subgroup long-term prognosis is excellent for patients, despite left ventricular dysfunction, if preoperative exercise capacity is preserved. In these patients, left ventricular dysfunction is likely to be reversible after operation. Hence, all patients with left ventricular dysfunction at rest should undergo aortic valve replacement, even if severe symptoms and deterioration in exercise tolerance have not developed. Once exercise tolerance becomes limited in such patients, the likelihood of irreversible left ventricular dysfunction is increased, and long-term postoperative survival is threatened.
R O Bonow; D R Rosing; K M Kent; S E Epstein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  50     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  325-36     Citation Subset:  AIM; IM    
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MeSH Terms
Aortic Valve
Aortic Valve Insufficiency / diagnosis,  mortality,  surgery*
Exercise Test
Heart Failure / prevention & control
Heart Valve Prosthesis*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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