Document Detail


Timing of mutation in influenza A virus hemagglutinins by means of amino-acid distribution rank and fast Fourier transform.
MedLine Citation:
PMID:  16472076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we calculated the amino-acid distribution rank of 1201 hemagglutinins from influenza A viruses dated from 1918 to 2004 in order to compare them with respect to subtypes, species and years. After noticing fluctuations in distribution rank along the time course, we used the fast Fourier transform to determine the mutation periodicity of the hemagglutinins. Then we estimated our position at the current cycle of hemagglutinin evolutionary process to determine how many years remain before the next possible outbreak of influenza and bird flu. Finally, we used the trend channel to outlook the future of hemagglutinins for the next half a century. As our study covers almost all the full-length amino-acid sequences of hemagglutinins from various influenza A viruses, the conclusions will be valid for years until the number of hemagglutinins in Protein Databank is significantly increased.
Authors:
Guang Wu; Shaomin Yan
Related Documents :
2994566 - Rabbit skeletal muscle acylphosphatase: the amino acid sequence of form ra1.
11902666 - Primary structure characterization of bothrops jararacussu snake venom lectin.
7501636 - Cloning and immunological characterisation of echinococcus granulosus ferritin.
8019136 - Automated sequencing of amino acid spin systems in proteins using multidimensional hcc(...
12500946 - Treatment of the rat hepatic stellate cell line, pav-1, by retinol and palmitic acid le...
8431936 - The gum exudate of encephalartos longifolius lehm. (female): further hydrolytic studies.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Protein and peptide letters     Volume:  13     ISSN:  0929-8665     ISO Abbreviation:  Protein Pept. Lett.     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-13     Completed Date:  2006-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441434     Medline TA:  Protein Pept Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  143-8     Citation Subset:  IM    
Affiliation:
Computational Mutation Project, DreamSciTech Consulting, 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province, CN-518054, China. hongguanglishibahao@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*,  genetics
Animals
Evolution, Molecular*
Hemagglutinin Glycoproteins, Influenza Virus / chemistry*,  genetics*
Humans
Influenza A virus / chemistry*,  classification,  genetics*,  pathogenicity
Mutation / genetics
Orthomyxoviridae Infections / virology*
Periodicity
Time Factors
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Hemagglutinin Glycoproteins, Influenza Virus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synthesis, characterization and biological activity of chemically modified insulin derivative with a...
Next Document:  Asparaginase display of human cholesteryl ester transfer protein (CETP) B cell epitopes for inducing...