Document Detail

Timing of mutation in influenza A virus hemagglutinins by means of amino-acid distribution rank and fast Fourier transform.
MedLine Citation:
PMID:  16472076     Owner:  NLM     Status:  MEDLINE    
In this study, we calculated the amino-acid distribution rank of 1201 hemagglutinins from influenza A viruses dated from 1918 to 2004 in order to compare them with respect to subtypes, species and years. After noticing fluctuations in distribution rank along the time course, we used the fast Fourier transform to determine the mutation periodicity of the hemagglutinins. Then we estimated our position at the current cycle of hemagglutinin evolutionary process to determine how many years remain before the next possible outbreak of influenza and bird flu. Finally, we used the trend channel to outlook the future of hemagglutinins for the next half a century. As our study covers almost all the full-length amino-acid sequences of hemagglutinins from various influenza A viruses, the conclusions will be valid for years until the number of hemagglutinins in Protein Databank is significantly increased.
Guang Wu; Shaomin Yan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Protein and peptide letters     Volume:  13     ISSN:  0929-8665     ISO Abbreviation:  Protein Pept. Lett.     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-13     Completed Date:  2006-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441434     Medline TA:  Protein Pept Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  143-8     Citation Subset:  IM    
Computational Mutation Project, DreamSciTech Consulting, 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province, CN-518054, China.
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MeSH Terms
Amino Acids / chemistry*,  genetics
Evolution, Molecular*
Hemagglutinin Glycoproteins, Influenza Virus / chemistry*,  genetics*
Influenza A virus / chemistry*,  classification,  genetics*,  pathogenicity
Mutation / genetics
Orthomyxoviridae Infections / virology*
Time Factors
Reg. No./Substance:
0/Amino Acids; 0/Hemagglutinin Glycoproteins, Influenza Virus

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