Document Detail


Timing of mortality in severe acute pancreatitis: experience from 643 patients.
MedLine Citation:
PMID:  17461498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To determine the timing of mortality after onset of severe acute pancreatitis (SAP) and the course of the disease in a large series of patients. METHODS: From July 1996 to June 2005, all patients diagnosed with acute pancreatitis at Chang Gung Memorial Hospital, Taipei, Taiwan were retrospectively studied. Three thousand two hundred and fifty episodes of acute pancreatitis were recorded in 2248 patients (1431 males and 817 females; median age, 55.6 years; range, 18-97 years). Mortality was divided into two groups: early death (<= 14 d after admission), and late death (> 14 d after admission). The clinical features of patients in these two groups were compared. RESULTS: Although the overall mortality rate of acute pancreatitis was 3.8% (123/3250), mortality rate of SAP was as high as 16.3% (105/643). Of those 105 SAP mortalities, 44 (41.9%) deaths occurred within the first 14 d after admission and 61 (58.1%) occurred after14 d. Incidence of early death did not significantly differ from that of late death. The co-morbidities did not contribute to the timing of death. Early deaths mainly resulted from multiple organ failure. Late deaths were mainly caused by secondary complication of infected necrosis. Intra-abdominal bleeding significantly caused higher mortality in late death. CONCLUSION: Approximately half (42%) of SAP deaths occur within 14 d and most were due to multiple organ failure. The late deaths of SAP were mostly due to infected necrosis.
Authors:
Chih-Yuan Fu; Chun-Nan Yeh; Jun-Te Hsu; Yi-Yin Jan; Tsann-Long Hwang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  13     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1966-9     Citation Subset:  IM    
Affiliation:
Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5 Fu-shin Street, Kweishan, Taoyuan, Taiwan, China.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Disease Progression
Female
Humans
Male
Middle Aged
Multiple Organ Failure / etiology,  mortality
Necrosis / etiology,  mortality
Pancreatitis / complications*,  mortality*
Retrospective Studies
Severity of Illness Index
Taiwan / epidemiology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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