Document Detail


Timing of maternal and neonatal dosing of nevirapine and the risk of mother-to-child transmission of HIV-1: HIVNET 024.
MedLine Citation:
PMID:  16227794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Despite a growing emphasis worldwide on complex and potent antiretroviral drug regimens for the prevention of mother-to-child transmission of HIV-1 (MTCT), two-dose nevirapine (NVP) prophylaxis remains an important choice in many settings. We analyzed data from a multicenter clinical trial to determine whether timing of maternal or infant NVP was associated with MTCT between delivery and 6 weeks of age (intrapartum/early postnatal transmission; I/EP). METHODS: HIVNET 024 was a placebo-controlled, double-blind trial of empiric antibiotics to reduce chorioamnionitis-associated MTCT. This secondary analysis used data collected in the original randomized trial. Enrolled women were instructed to self-administer NVP at labor onset; infants were to receive a dose within 72 h of birth. RESULTS: Data regarding 1491 mother-infant pairs were analyzed. The overall I/EP HIV-1 transmission rate was 8.1% at 6 weeks. Almost all women (93%) ingested NVP within 24 h of delivery; 90% of infants were given NVP within 48 h after delivery. Variations in mother or infant dose timing did not influence transmission rates, even when the combined pattern of both was taken into account through multivariate analysis. In the subset of women ingesting NVP <or= 2 h before delivery, early NVP administration to the infant (< 4 h after birth) was not associated with lower MTCT risk when compared with later administration (>or= 4 h). CONCLUSION: Variations in the timing of maternal and infant NVP doses (within reasonable proximity to delivery) do not appear to affect the risk of MTCT.
Authors:
Benjamin H Chi; Lei Wang; Jennifer S Read; Muhsin Sheriff; Susan Fiscus; Elizabeth R Brown; Taha E Taha; Megan Valentine; Robert Goldenberg
Related Documents :
23210694 - Duration of vancomycin treatment for coagulase-negative staphylococcus sepsis in very-l...
9498474 - Risk of severe malaria among african infants: direct evidence of clinical protection du...
22088784 - Cerebral and mesenteric tissue oxygenation by positional changes in very low birth weig...
1524264 - Evaluation of prophylaxis against hepatitis b in a large municipal hospital.
8414714 - Apnea spells, sudden death, and the role of the apnea monitor.
17988374 - Intimate partner violence and infant morbidity: evidence of an association from a popul...
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS (London, England)     Volume:  19     ISSN:  0269-9370     ISO Abbreviation:  AIDS     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-06-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1857-64     Citation Subset:  IM; X    
Affiliation:
University of Alabama at Birmingham, Department of Obstetrics & Gynecology, Birmingham, Alabama, USA. bchi@cidrz.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / administration & dosage*
Double-Blind Method
Drug Administration Schedule
Female
HIV Infections / drug therapy,  transmission*
Humans
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Nevirapine / administration & dosage*
Pregnancy
Pregnancy Complications, Infectious / drug therapy*
Risk Factors
Self Administration
Time Factors
Grant Support
ID/Acronym/Agency:
N01-AI-35173/AI/NIAID NIH HHS; N01-AI-35173-117/412/AI/NIAID NIH HHS; N01-AI-45200/AI/NIAID NIH HHS; U01-AI-47972/AI/NIAID NIH HHS; U01-AI-480006/AI/NIAID NIH HHS; U01-AI-48005/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 129618-40-2/Nevirapine
Comments/Corrections
Comment In:
AIDS. 2006 Apr 24;20(7):1059-60   [PMID:  16603859 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effects of maternal helminth and malaria infections on mother-to-child HIV transmission.
Next Document:  Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing mother-to-ch...