Document Detail

Timing of maternal and neonatal dosing of nevirapine and the risk of mother-to-child transmission of HIV-1: HIVNET 024.
MedLine Citation:
PMID:  16227794     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Despite a growing emphasis worldwide on complex and potent antiretroviral drug regimens for the prevention of mother-to-child transmission of HIV-1 (MTCT), two-dose nevirapine (NVP) prophylaxis remains an important choice in many settings. We analyzed data from a multicenter clinical trial to determine whether timing of maternal or infant NVP was associated with MTCT between delivery and 6 weeks of age (intrapartum/early postnatal transmission; I/EP). METHODS: HIVNET 024 was a placebo-controlled, double-blind trial of empiric antibiotics to reduce chorioamnionitis-associated MTCT. This secondary analysis used data collected in the original randomized trial. Enrolled women were instructed to self-administer NVP at labor onset; infants were to receive a dose within 72 h of birth. RESULTS: Data regarding 1491 mother-infant pairs were analyzed. The overall I/EP HIV-1 transmission rate was 8.1% at 6 weeks. Almost all women (93%) ingested NVP within 24 h of delivery; 90% of infants were given NVP within 48 h after delivery. Variations in mother or infant dose timing did not influence transmission rates, even when the combined pattern of both was taken into account through multivariate analysis. In the subset of women ingesting NVP <or= 2 h before delivery, early NVP administration to the infant (< 4 h after birth) was not associated with lower MTCT risk when compared with later administration (>or= 4 h). CONCLUSION: Variations in the timing of maternal and infant NVP doses (within reasonable proximity to delivery) do not appear to affect the risk of MTCT.
Benjamin H Chi; Lei Wang; Jennifer S Read; Muhsin Sheriff; Susan Fiscus; Elizabeth R Brown; Taha E Taha; Megan Valentine; Robert Goldenberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS (London, England)     Volume:  19     ISSN:  0269-9370     ISO Abbreviation:  AIDS     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-06-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1857-64     Citation Subset:  IM; X    
University of Alabama at Birmingham, Department of Obstetrics & Gynecology, Birmingham, Alabama, USA.
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MeSH Terms
Anti-HIV Agents / administration & dosage*
Double-Blind Method
Drug Administration Schedule
HIV Infections / drug therapy,  transmission*
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Nevirapine / administration & dosage*
Pregnancy Complications, Infectious / drug therapy*
Risk Factors
Self Administration
Time Factors
Grant Support
N01-AI-35173/AI/NIAID NIH HHS; N01-AI-35173-117/412/AI/NIAID NIH HHS; N01-AI-45200/AI/NIAID NIH HHS; U01-AI-47972/AI/NIAID NIH HHS; U01-AI-480006/AI/NIAID NIH HHS; U01-AI-48005/AI/NIAID NIH HHS
Reg. No./Substance:
0/Anti-HIV Agents; 129618-40-2/Nevirapine
Comment In:
AIDS. 2006 Apr 24;20(7):1059-60   [PMID:  16603859 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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