Document Detail

Timing of life-threatening arrhythmias detected by implantable cardioverter-defibrillators in relation to changes in cosmophysical factors.
MedLine Citation:
PMID:  18810718     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Studies have linked the natural history of many pathologies with environmental physical activity. This study investigated the relationship between the occurrence of ventricular tachycardia/fibrillation (VT/VF) recorded by implantable cardioverter defibrillators (ICD) and geomagnetic and cosmic ray (neutron) activity. METHODS: The study group included 85 patients (73 men) with cardiomyopathy (80% ischemic) who underwent ICD placement in the years 1995-2006; 74% had a left ventricular ejection fraction of < 30%. Data on the days on which VT/VF occurred (total number of days: 284) and the days on which the patients were treated (total number of treatments: 580) were collected from the ICD records. The findings were analyzed against levels of geomagnetic activity (GMA) (I degree -IV degree) and cosmic ray activity (CRA), derived from international observatories, on the same days and throughout the study period. RESULTS: On days of VT/VF, daily values of GMA level averaged 1.5 +/- 0.7, consistent with level I degree (quiet). The ratios of daily VT/VF episodes and treatment to GMA level for the whole study period were as follows: 1.2 level I; 0.9 level II; 0.69 level III; 0.78 level IV (r = -0.974; p = 0.02). Mean CRA on days of VT/VF was 9246.8 +/- 299.0 imp/min, and for all 4383 days studied, 8805.33 +/- 411.4 imp/min (p < 0.0001). CONCLUSIONS: In patients with predominantly ischemic cardiomyopathy and severe left ventricular dysfunction, VT/VF occurs more often on days of low GMA and high CRA. Further studies are needed to determine the underlying mechanism of the effect of neutron activity on cardiac electrical instability.
Elyiahu Stoupel; Jairo Kusniec; Alexander Mazur; Evgeny Abramson; Peter Israelevich; Boris Strasberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology journal     Volume:  15     ISSN:  1897-5593     ISO Abbreviation:  -     Publication Date:  2008  
Date Detail:
Created Date:  2008-09-23     Completed Date:  2008-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  437-40     Citation Subset:  IM    
Division of Cardiology, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Israel.
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MeSH Terms
Aged, 80 and over
Cardiomyopathies / complications
Cosmic Radiation*
Death, Sudden, Cardiac / etiology
Defibrillators, Implantable*
Geological Phenomena
Middle Aged
Myocardial Ischemia / complications
Tachycardia, Ventricular / diagnosis*,  etiology*,  therapy
Ventricular Fibrillation / diagnosis,  etiology,  therapy

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