Document Detail


Timing of leukocyte filtration during cardiopulmonary bypass.
MedLine Citation:
PMID:  11334204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of leukocyte filtration on the outcome of cardiac surgery with cardiopulmonary bypass (CPB) have been shown by numerous investigators. In the majority of cases a leukocyte filter is placed in the arterial line instead of a standard arterial line filter and used throughout CPB. However, protocols to optimize onset and duration of leukocyte filtration have not been sufficiently evaluated to date. In this paper, current efforts to improve such protocols are demonstrated and discussed. These efforts are based on studies of leukocyte pathogenicity during cardiac surgery. A first study (double-blind randomized) was performed in routine coronary artery bypass graft (CABG) patients to evaluate whether short-term leukocyte filtration during reperfusion by release of the aortic crossclamp would reduce reperfusion-associated myocardial damage. Further data compare the efficacy of three different filtration concepts to reduce CPB- and/or reperfusion-associated leukocyte pathogenicity. Clinical endpoints, standard laboratory variables and functional in vitro assays are provided and discussed.
Authors:
G Matheis; M Scholz; A Simon; D Henrich; G Wimmer-Greinecker; A Moritz
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Perfusion     Volume:  16 Suppl     ISSN:  0267-6591     ISO Abbreviation:  Perfusion     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-05-03     Completed Date:  2002-01-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8700166     Medline TA:  Perfusion     Country:  England    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
Affiliation:
Department of Thoracic and Cardiovascular Surgery, JW Goethe University, Frankfurt, Germany. matheis.gbr@gmx.de
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MeSH Terms
Descriptor/Qualifier:
Cardiopulmonary Bypass / methods*,  standards
Clinical Trials as Topic
Filtration / methods
Humans
Leukapheresis / standards*
Neutrophils / metabolism,  pathology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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