Document Detail


Timing of infant feeding in relation to childhood asthma and allergic diseases.
MedLine Citation:
PMID:  23182171     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Emerging evidence questions current recommendations on the timing of infant feeding for the prevention of childhood allergies. The evidence for asthma is inconclusive.
OBJECTIVE: We sought to investigate the associations between the duration of breast-feeding and timing of introduction of complementary foods and the development of asthma and allergies by the age of 5 years.
METHODS: Data were analyzed for 3781 consecutively born children. The dietary exposures were categorized into thirds and analyzed as time-dependent variables. Asthma, allergic rhinitis, and atopic eczema end points were assessed by using the International Study of Asthma and Allergies in Childhood questionnaire, whereas IgE antibodies were analyzed from serum samples at the age of 5 years. Cox proportional hazard and logistic regressions were used for the analyses.
RESULTS: The median duration of exclusive and total breast-feeding was 1.4 months (interquartile range, 0.2-3.5 months) and 7.0 months (interquartile range, 4.0-11.0 months), respectively. Total breast-feeding of 9.5 months or less was associated with an increased risk of nonatopic asthma. Introduction of wheat, rye, oats, or barley at 5 to 5.5 months was inversely associated with asthma and allergic rhinitis, whereas introduction of other cereals at less than 4.5 months increased the risk of atopic eczema. Introduction of egg at 11 months or less was inversely associated with asthma, allergic rhinitis, and atopic sensitization, whereas introduction of fish at 9 months or less was inversely associated with allergic rhinitis and atopic sensitization.
CONCLUSION: Early introduction of wheat, rye, oats, and barley cereals; fish; and egg (respective to the timing of introduction of each food) seems to decrease the risk of asthma, allergic rhinitis, and atopic sensitization in childhood. Longer duration of total breast-feeding, rather than its exclusivity, was protective against the development of nonatopic but not atopic asthma, suggesting a potential differing effect of breast-feeding on different asthma phenotypes.
Authors:
Bright I Nwaru; Hanna-Mari Takkinen; Onni Niemelä; Minna Kaila; Maijaliisa Erkkola; Suvi Ahonen; Anna-Maija Haapala; Michael G Kenward; Juha Pekkanen; Riitta Lahesmaa; Juha Kere; Olli Simell; Riitta Veijola; Jorma Ilonen; Heikki Hyöty; Mikael Knip; Suvi M Virtanen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-22
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  131     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-25     Completed Date:  2013-03-06     Revised Date:  2014-02-07    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  78-86     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Asthma / epidemiology,  etiology*
Breast Feeding*
Child, Preschool
Diet*
Female
Humans
Hypersensitivity / epidemiology,  etiology*
Male
Questionnaires
Time Factors
Comments/Corrections
Comment In:
Am Fam Physician. 2013 Dec 15;88(12):818-20   [PMID:  24364544 ]

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