Document Detail


Timing of impulses from the central amygdala and bed nucleus of the stria terminalis to the brain stem.
MedLine Citation:
PMID:  18971295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The amygdala and bed nucleus of the stria terminalis (BNST) are thought to subserve distinct functions, with the former mediating rapid fear responses to discrete sensory cues and the latter longer "anxiety-like" states in response to diffuse environmental contingencies. However, these structures are reciprocally connected and their projection sites overlap extensively. To shed light on the significance of BNST-amygdala connections, we compared the antidromic response latencies of BNST and central amygdala (CE) neurons to brain stem stimulation. Whereas the frequency distribution of latencies was unimodal in BNST neurons (approximately 10-ms mode), that of CE neurons was bimodal (approximately 10- and approximately 30-ms modes). However, after stria terminalis (ST) lesions, only short-latency antidromic responses were observed, suggesting that CE axons with long conduction times course through the ST. Compared with the direct route, the ST greatly lengthens the path of CE axons to the brain stem, an apparently disadvantageous arrangement. Because BNST and CE share major excitatory basolateral amygdala (BL) inputs, lengthening the path of CE axons might allow synchronization of BNST and CE impulses to brain stem when activated by BL. To test this, we applied electrical BL stimuli and compared orthodromic response latencies in CE and BNST neurons. The latency difference between CE and BNST neurons to BL stimuli approximated that seen between the antidromic responses of BNST cells and CE neurons with long conduction times. These results point to a hitherto unsuspected level of temporal coordination between the inputs and outputs of CE and BNST neurons, supporting the idea of shared functions.
Authors:
Frank Z Nagy; Denis Paré
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-10-29
Journal Detail:
Title:  Journal of neurophysiology     Volume:  100     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-08     Completed Date:  2009-04-23     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3429-36     Citation Subset:  IM    
Affiliation:
Center for Molecular and Behavioral Neuroscience, The State University of New Jersey, Newark, NJ 07102, USA.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Amygdala / cytology,  physiology*
Animals
Brain Mapping
Brain Stem / cytology,  physiology*
Efferent Pathways / physiology
Electric Stimulation / methods
Male
Neurons / physiology*
Rats
Rats, Sprague-Dawley
Reaction Time / physiology*
Septal Nuclei / cytology,  injuries,  physiology*
Grant Support
ID/Acronym/Agency:
R01 MH-073610/MH/NIMH NIH HHS
Comments/Corrections

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