Document Detail

Timing of human chorionic gonadotrophin (hCG) hormone administration in IVF protocols using GnRH antagonists: a randomized controlled trial.
MedLine Citation:
PMID:  22812907     Owner:  NLM     Status:  MEDLINE    
This randomized controlled trial investigated whether delaying human chorionic gonadotrophin hormone (hCG) administration within an IVF cycle impacts upon clinical outcomes. Participants included 125 women undergoing IVF/ICSI cycles at Leeds Centre for Reproductive Medicine. Subjects were aged 20-36 years, body mass index (BMI) 20-30 kg/m(2) with a normal FSH level (<8 IU/l). Administration of hCG took place 35-36 h prior to oocyte retrieval when there were ≥3 follicles ≥17 mm in diameter (Group A), delayed by 1 day (Group B) or 2 days (Group C). Outcomes included the number of oocytes retrieved per cycle, fertilization rate and live birth rate. On the day of oocyte retrieval, women in Groups B and C had significantly more mature follicles than Group A, although the number of oocytes retrieved did not differ (median = 12 in each group). Fertilization rates and embryo quality were comparable between groups. Pregnancies and live births per cycle were higher in Groups B and C (A = 30.8%, B = 54.1%, C = 38.7%; A = 17.9%, B = 27.0%, C = 25.8%), but did not reach statistical significance. Delaying hCG administration had no significant negative impact upon morphological quality of embryos, availability of surplus embryos for freezing or pregnancy outcomes. Postponing hCG may enable increased flexibility of cycle scheduling to avoid weekend procedures.
L Morley; T Tang; E Yasmin; R Hamzeh; A J Rutherford; A H Balen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human fertility (Cambridge, England)     Volume:  15     ISSN:  1742-8149     ISO Abbreviation:  Hum Fertil (Camb)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2013-01-03     Revised Date:  2013-02-07    
Medline Journal Info:
Nlm Unique ID:  100888143     Medline TA:  Hum Fertil (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  134-9     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, St James's University Hospital, Leeds, UK.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage*
Fertilization in Vitro / methods*
Gonadotropin-Releasing Hormone / antagonists & inhibitors*
Live Birth
Oocyte Retrieval
Sperm Injections, Intracytoplasmic / methods
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Chorionic Gonadotropin; 33515-09-2/Gonadotropin-Releasing Hormone
Comment In:
Hum Fertil (Camb). 2012 Dec;15(4):221   [PMID:  23190259 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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