Document Detail


Timing of food intake predicts weight loss effectiveness.
MedLine Citation:
PMID:  23357955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is emerging literature demonstrating a relationship between the timing of feeding and weight regulation in animals. However, whether the timing of food intake influences the success of a weight-loss diet in humans is unknown.
OBJECTIVE: To evaluate the role of food timing in weight-loss effectiveness in a sample of 420 individuals who followed a 20-week weight-loss treatment.
METHODS: Participants (49.5% female subjects; age (mean ± s.d.): 42 ± 11 years; BMI: 31.4 ± 5.4 kg m(-2)) were grouped in early eaters and late eaters, according to the timing of the main meal (lunch in this Mediterranean population). 51% of the subjects were early eaters and 49% were late eaters (lunch time before and after 1500 hours, respectively), energy intake and expenditure, appetite hormones, CLOCK genotype, sleep duration and chronotype were studied.
RESULTS: Late lunch eaters lost less weight and displayed a slower weight-loss rate during the 20 weeks of treatment than early eaters (P=0.002). Surprisingly, energy intake, dietary composition, estimated energy expenditure, appetite hormones and sleep duration was similar between both groups. Nevertheless, late eaters were more evening types, had less energetic breakfasts and skipped breakfast more frequently that early eaters (all; P<0.05). CLOCK rs4580704 single nucleotide polymorphism (SNP) associated with the timing of the main meal (P=0.015) with a higher frequency of minor allele (C) carriers among the late eaters (P=0.041). Neither sleep duration, nor CLOCK SNPs or morning/evening chronotype was independently associated with weight loss (all; P>0.05).
CONCLUSIONS: Eating late may influence the success of weight-loss therapy. Novel therapeutic strategies should incorporate not only the caloric intake and macronutrient distribution - as is classically done - but also the timing of food.
Authors:
M Garaulet; P Gómez-Abellán; J J Alburquerque-Béjar; Y-C Lee; J M Ordovás; F A J L Scheer
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-01-29
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  37     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-11-08     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  604-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
CLOCK Proteins / genetics
Circadian Rhythm
Diet, Mediterranean
Energy Intake
Energy Metabolism
Female
Food Habits*
Genotype
Ghrelin / blood
Humans
Leptin / blood
Male
Obesity / blood,  diet therapy*,  epidemiology
Predictive Value of Tests
Questionnaires
Sleep
Spain / epidemiology
Time Factors
Treatment Outcome
Weight Loss* / genetics
Weight Reduction Programs / methods*
Grant Support
ID/Acronym/Agency:
DK075030/DK/NIDDK NIH HHS; HL-54776/HL/NHLBI NIH HHS; R01 DK075030/DK/NIDDK NIH HHS; R01 HL054776/HL/NHLBI NIH HHS; R01 HL094806/HL/NHLBI NIH HHS; R01 HL094806/HL/NHLBI NIH HHS; R21 DK089378/DK/NIDDK NIH HHS; R21 DK089378/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Leptin; EC 2.3.1.48/CLOCK Proteins; EC 2.3.1.48/CLOCK protein, human
Comments/Corrections
Erratum In:
Int J Obes (Lond). 2013 Apr;37(4):624

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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