Document Detail

Timing of fetal nucleated red blood cell count elevation in response to acute hypoxia.
MedLine Citation:
PMID:  14691347     Owner:  NLM     Status:  MEDLINE    
We determined the effect of an acute episode of severe hypoxia on peripheral nucleated red blood cell (RBC) counts in the fetal rat. Timed pregnant rats were randomized to a 2-hour exposure to hypoxia (placement in a chamber containing a gas mixture with 9% O2 +3% CO2 + balanced N2) or to a 2-hour exposure to a sham chamber containing room air. Two maternal animals per group underwent cesarean section immediately after the 2-hour period and then 4, 12, 24, 36, 48, and 60 h after exposure. Fetal nucleated RBC counts were compared between groups at each time interval. The nucleated RBC counts were not significantly different in the hypoxia group until 12 h (mean +/- SEM 158.0 +/- 22.4 RBC/10 high-power fields vs. 90.6 +/- 11.0; p = 0.03) and 24 h (133.2 +/- 16.0 vs. 84.1 +/- 9.0; p = 0.04) after exposure. There were no differences between groups 36, 48, and 60 h after exposure. In the near-term rat fetus, acute hypoxia was associated with a delayed but transient increase in peripheral nucleated RBC counts.
Sean C Blackwell; Mordechai Hallak; John W Hotra; Jerrie Refuerzo; Sonia S Hassan; Robert J Sokol; Yoram Sorokin
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Publication Detail:
Type:  Journal Article     Date:  2003-12-23
Journal Detail:
Title:  Biology of the neonate     Volume:  85     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-22     Completed Date:  2004-12-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
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MeSH Terms
Erythroblasts / cytology*
Erythrocyte Count*
Fetal Blood / cytology*
Fetal Hypoxia / blood*
Rats, Long-Evans
Time Factors

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