Document Detail


Timing of fetal exposure to stress hormones: effects on newborn physical and neuromuscular maturation.
MedLine Citation:
PMID:  18335490     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the study was to determine the specific periods during pregnancy in which human fetal exposure to stress hormones affects newborn physical and neuromuscular maturation. Blood was collected from 158 women at 15, 19, 25, and 31 weeks' gestation. Levels of placental corticotropin-releasing hormone (CRH) and maternal cortisol were determined from plasma. Newborns were evaluated with the New Ballard Maturation Score. Results indicated that increases in maternal cortisol at 15, 19, and 25 weeks and increases in placental CRH at 31 weeks were significantly associated with decreases in infant maturation among males (even after controlling for length of gestation). Results also suggested that increases in maternal cortisol at 31 weeks were associated with increases in infant maturation among females, although these results were not significant after controlling for length of gestation. Findings suggest that stress hormones have effects on human fetal neurodevelopment that are independent of birth outcome.
Authors:
Lauren M Ellman; Christine Dunkel Schetter; Calvin J Hobel; Aleksandra Chicz-Demet; Laura M Glynn; Curt A Sandman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental psychobiology     Volume:  50     ISSN:  1098-2302     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-04-14     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight*
Corticotropin-Releasing Hormone / blood*
Female
Fetal Growth Retardation / blood*,  diagnosis
Gestational Age*
Humans
Hydrocortisone / blood*
Hypothalamo-Hypophyseal System / physiopathology
Infant, Newborn
Male
Neurologic Examination*
Neuromuscular Diseases / blood*,  diagnosis
Pituitary-Adrenal System / physiopathology
Pregnancy
Prenatal Exposure Delayed Effects*
Risk Factors
Stress, Psychological / blood,  complications*
Grant Support
ID/Acronym/Agency:
HD28413/HD/NICHD NIH HHS; MH15750/MH/NIMH NIH HHS; R01 HD028413/HD/NICHD NIH HHS; R01 HD028413-06/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9015-71-8/Corticotropin-Releasing Hormone; WI4X0X7BPJ/Hydrocortisone
Comments/Corrections

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