| Timing of fetal exposure to stress hormones: effects on newborn physical and neuromuscular maturation. | |
| | |
MedLine Citation:
|
PMID: 18335490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of the study was to determine the specific periods during pregnancy in which human fetal exposure to stress hormones affects newborn physical and neuromuscular maturation. Blood was collected from 158 women at 15, 19, 25, and 31 weeks' gestation. Levels of placental corticotropin-releasing hormone (CRH) and maternal cortisol were determined from plasma. Newborns were evaluated with the New Ballard Maturation Score. Results indicated that increases in maternal cortisol at 15, 19, and 25 weeks and increases in placental CRH at 31 weeks were significantly associated with decreases in infant maturation among males (even after controlling for length of gestation). Results also suggested that increases in maternal cortisol at 31 weeks were associated with increases in infant maturation among females, although these results were not significant after controlling for length of gestation. Findings suggest that stress hormones have effects on human fetal neurodevelopment that are independent of birth outcome. |
| | |
Authors:
|
Lauren M Ellman; Christine Dunkel Schetter; Calvin J Hobel; Aleksandra Chicz-Demet; Laura M Glynn; Curt A Sandman |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Developmental psychobiology Volume: 50 ISSN: 1098-2302 ISO Abbreviation: Dev Psychobiol Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-03-17 Completed Date: 2008-04-14 Revised Date: 2011-04-21 |
Medline Journal Info:
|
Nlm Unique ID: 0164074 Medline TA: Dev Psychobiol Country: United States |
Other Details:
|
Languages: eng Pagination: 232-41 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 23, New York, New York 10032, USA. le2194@columbia.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Birth Weight* Corticotropin-Releasing Hormone / blood* Female Fetal Growth Retardation / blood*, diagnosis Gestational Age* Humans Hydrocortisone / blood* Hypothalamo-Hypophyseal System / physiopathology Infant, Newborn Male Neurologic Examination* Neuromuscular Diseases / blood*, diagnosis Pituitary-Adrenal System / physiopathology Pregnancy Prenatal Exposure Delayed Effects* Risk Factors Stress, Psychological / blood, complications* |
| Grant Support | |
ID/Acronym/Agency:
|
HD28413/HD/NICHD NIH HHS; MH15750/MH/NIMH NIH HHS; R01 HD028413-06/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intra-individual variability in infancy: structure, stability, and nutritional correlates.
Next Document: Role and regulation of human XRCC4-like factor/cernunnos.