Document Detail

Timing of exogenous surfactant administration in a rabbit model of acute lung injury.
MedLine Citation:
PMID:  8926267     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate early vs. late administration of exogenous surfactant in an adult rabbit model of acute lung injury. Lung injury was induced by repetitive whole lung saline lavage and subsequent mechanical ventilation. Bovine lipid extract surfactant was instilled either 1 (Early) or 4 h (Late) after the last lavage. Animals were monitored for 7 h after the last lavage. Although arterial PO2 values increased significantly immediately after treatment in both the Early and Late groups, this improvement was not sustained in the Late group. There was also a higher incidence of pneumothoraxes in the Late group vs. both the Early group and a nontreated control group. The ratio of poorly functioning small surfactant aggregates to superior functioning large aggregates was higher in the Late group compared with the Early group. Morphological analysis revealed that early surfactant treatment prevented the progression of lung injury over time. We conclude that administration of exogenous surfactant at an early time point in lung injury resulted in superior responses compared with later treatments.
Y Ito; J Goffin; R Veldhuizen; M Joseph; D Bjarneson; L McCaig; L J Yao; J Marcou; J Lewis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  80     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-11-27     Completed Date:  1996-11-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1357-64     Citation Subset:  IM    
Lawson Research Institute, St. Joseph's Health Centre, Department of Physiology, University of Western Ontario, London, Canada.
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MeSH Terms
Disease Models, Animal
Lung / ultrastructure
Pulmonary Gas Exchange
Respiratory Distress Syndrome, Adult / drug therapy*
Respiratory Function Tests
Surface-Active Agents / pharmacology*
Time Factors
Reg. No./Substance:
0/Surface-Active Agents

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