| Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- mice. | |
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MedLine Citation:
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PMID: 18374339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies of the effects of estrogen replacement therapy on coronary heart disease risk have produced conflicting results. We hypothesize that this may be explained by differences in the length of estrogen deficiency prior to initiation of treatment and associated variation in plaque inflammation or stage of progression. The goal of this study was to determine whether estrogen administered after a period of deficiency affects plaque progression and leukocyte populations. Ovariectomized ApoE-/- mice were treated as follows: group 1: continuous estrogen for 90 days (E+/+); group 2: placebo for 45 days followed by estrogen for 45 days (E-/+); group 3: estrogen for 45 days followed by placebo for 45 days (E+/-); and group 4: placebo for 90 days (E-/-). Serum lipoprotein concentrations, plaque size and inflammatory cell (macrophage, CD3+, CD4+, CD8+, dendritic cell, and NK cell) densities were quantified. Plaque size was smaller in groups receiving early estrogen therapy. CD3+ and total inflammatory cell densities were lower in late estrogen therapy groups. The CD8 to dendritic cell ratio was significantly lower in the E-/+ group only. These results suggest that a period of estrogen deficiency followed by reintroduction alters the immunologic environment of atherosclerotic lesions as well as plaque progression. |
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Authors:
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Jennifer A Cann; Thomas C Register; Michael R Adams; Richard W St Clair; Mark A Espeland; J Koudy Williams |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-02-21 |
Journal Detail:
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Title: Atherosclerosis Volume: 201 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2009-10-30 Completed Date: 2010-01-26 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 43-52 Citation Subset: IM |
Affiliation:
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Department of Pathology, Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157, United States. jcann@wfubmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoproteins E / physiology* Atherosclerosis / blood*, etiology, pathology* Drug Administration Schedule Estradiol / administration & dosage* Estrogen Replacement Therapy* Estrogens / administration & dosage* Female Leukocyte Count Mice Mice, Inbred C57BL Ovariectomy |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG017864-05/AG/NIA NIH HHS; R01AG17864/AG/NIA NIH HHS; T32 RR 07009/RR/NCRR NIH HHS; T32 RR007009-22/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Estrogens; 50-28-2/Estradiol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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