Document Detail


Timing of disease progression by quantitative EEG in Alzheimer' s patients.
MedLine Citation:
PMID:  10600024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This prospective study was planned to assess whether quantitative EEG (qEEG) can give an estimate of the timing of achievement of three endpoints (loss of activities of daily living, incontinence, and death) in 72 consecutive patients (53 females, 19 males; mean age, 70.8) affected with probable Alzheimer's disease, as defined according to the NINCDS-ADRDA criteria. Power-weighted, log-transformed relative values of the four conventional EEG bands were considered in a central-posterior temporal region for each hemisphere. The hypothesis was tested by the lifereg procedure of the Statistical Analysis System package (first significance level accepted, P < or = 0.01). Because patients were in different stages of the disease, the statistical analysis was performed in the entire group as well as in the subgroup of 41 patients (mean age, 69.6) with mild dementia (scoring 3 or 4 on the global deterioration scale). In the whole group, the loss of activities of daily living was predicted by delta power in either side (P = 0.01), incontinence was predicted by alpha power in the right side (P < 0.01), whereas the statistical significance was not reached for death (P < 0.05). In the subgroup of mild demented patients, the loss of activities of daily living was predicted by delta power in the left side (P = 0.01), incontinence by both delta (P < 0.01) and alpha (P < 0.001) power in the right side, and death was not significantly predicted (P = 0.08). Quantitative EEG is a low-cost, discomfort-free technique which may be used to obtain information on the timing of disease evolution. The results showed in mild Alzheimer's disease appear especially interesting to attempt a prediction of the future time course of the disease from its beginning.
Authors:
F Nobili; F Copello; P Vitali; T Prastaro; S Carozzo; G Perego; G Rodriguez
Related Documents :
15066674 - Topiramate: effect on eeg interictal abnormalities and background activity in patients ...
6496034 - Reflex epilepsy evoked by specific psychic activity. a case report.
8937534 - Eeg reactivity correlates with neuropsychological test scores in down's syndrome.
16499764 - Epilepsy in menkes disease: analysis of clinical stages.
15715454 - Nondysraphic intramedullary spinal cord lipomas: a review.
20361294 - Motor-dominant chronic inflammatory demyelinating polyneuropathy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society     Volume:  16     ISSN:  0736-0258     ISO Abbreviation:  J Clin Neurophysiol     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-04     Completed Date:  2000-01-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8506708     Medline TA:  J Clin Neurophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  566-73     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Genova, S. Martino Hospital, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Activities of Daily Living
Aged
Aged, 80 and over
Alzheimer Disease / complications,  mortality,  physiopathology*
Disease Progression
Electroencephalography*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Questionnaires
Statistical Distributions
Urinary Incontinence / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Task-dependent effects on motor-evoked potentials and on the following silent period.
Next Document:  Epitopes and functional responses defined by a panel of anti-Fas (CD95) monoclonal antibodies.