Document Detail

Timing of cochlear responses inferred from frequency-threshold tuning curves of auditory-nerve fibers.
MedLine Citation:
PMID:  20951191     Owner:  NLM     Status:  MEDLINE    
Links between frequency tuning and timing were explored in the responses to sound of auditory-nerve fibers. Synthetic transfer functions were constructed by combining filter functions, derived via minimum-phase computations from average frequency-threshold tuning curves of chinchilla auditory-nerve fibers with high spontaneous activity (Temchin et al., 2008), and signal-front delays specified by the latencies of basilar-membrane and auditory-nerve fiber responses to intense clicks (Temchin et al., 2005). The transfer functions predict several features of the phase-frequency curves of cochlear responses to tones, including their shape transitions in the regions with characteristic frequencies of 1 kHz and 3-4 kHz (Temchin and Ruggero, 2010). The transfer functions also predict the shapes of cochlear impulse responses, including the polarities of their frequency sweeps and their transition at characteristic frequencies around 1 kHz. Predictions are especially accurate for characteristic frequencies <1 kHz.
Andrei N Temchin; Alberto Recio-Spinoso; Mario A Ruggero
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-14
Journal Detail:
Title:  Hearing research     Volume:  272     ISSN:  1878-5891     ISO Abbreviation:  Hear. Res.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-06-07     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  178-86     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
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MeSH Terms
Acoustic Stimulation
Auditory Pathways / physiology*
Auditory Threshold
Basilar Membrane / innervation
Cochlea / innervation*
Cochlear Nerve / physiology*
Computer Simulation
Mechanotransduction, Cellular*
Models, Neurological*
Reaction Time
Time Factors
Grant Support
2 R01 DC000419-20A2/DC/NIDCD NIH HHS; R01 DC000419/DC/NIDCD NIH HHS; R01 DC000419-20A2/DC/NIDCD NIH HHS

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