Document Detail

Timing cell-fate determination during asymmetric cell divisions.
MedLine Citation:
PMID:  18983918     Owner:  NLM     Status:  MEDLINE    
From invertebrates to mammals, cell-cycle progression during an asymmetric cell division is accompanied by precisely timed redistribution of cell-fate determinants so that they segregate asymmetrically to enable the two daughter cells to choose different fates. Interestingly, studies on how cell fates are specified in such divisions reveal that the same fate determinants can be reiteratively used to specify a variety of cell types through multiple rounds of cell divisions or to exert seemingly contradictory effects on cell proliferation and differentiation. Here I summarize the molecular mechanisms governing asymmetric cell division and review recent findings pointing to a novel mechanism for coupling intracellular signaling and cell-cycle progression. This mechanism uses changes in the morphology, subcellular distribution, and molecular composition of cellular organelles like the Golgi apparatus and centrosomes, which not only accompany the progression of cell cycle to activate but also temporally constrain the activity of fate determinants during asymmetric cell divisions.
Weimin Zhong
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-11-12
Journal Detail:
Title:  Current opinion in neurobiology     Volume:  18     ISSN:  1873-6882     ISO Abbreviation:  Curr. Opin. Neurobiol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-02-20     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  9111376     Medline TA:  Curr Opin Neurobiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  472-8     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation / physiology*
Cell Division / physiology
Cell Lineage*
Golgi Apparatus / metabolism
Models, Biological
Neurons / cytology,  physiology*
Signal Transduction / physiology
Stem Cells / cytology,  physiology*
Grant Support
R01 NS042048/NS/NINDS NIH HHS; R01 NS042048-06/NS/NINDS NIH HHS; R01 NS042048-07/NS/NINDS NIH HHS; R01 NS042048-08/NS/NINDS NIH HHS; R21 HD065062/HD/NICHD NIH HHS

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