| Timing of cardiac contraction in humans mapped by high-temporal-resolution MRI tagging: early onset and late peak of shortening in lateral wall. | |
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MedLine Citation:
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PMID: 14726304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mechanical asynchrony is an important parameter in predicting the response to cardiac resynchronization therapy, but detailed knowledge of cardiac contraction timing in healthy persons is scarce. In this work, timing of cardiac contraction was mapped in 17 healthy subjects with high-temporal-resolution (14 ms) MRI myocardial tagging and strain analysis. Both the onset time of circumferential shortening (T(onset)) in early systole and the time of peak circumferential shortening (T(peak)) at end systole were determined. The onset of shortening width (time needed for 20-90% of the left ventricle to start shortening) was small (35 +/- 9 ms). A distinct spatial pattern for T(onset) was found, with earliest onset in the lateral wall and latest onset in the septum (P = 0.001). Compared with T(onset), T(peak) had a larger width (121 +/- 22 ms) and an opposite spatial pattern, with peak shortening occurring earlier in the septum than in the lateral wall (P < 0.001). Postsystolic shortening (T(peak) later than aortic valve closure; P < 0.05) was observed in 13 of the 30 cardiac segments, mainly in the lateral and basal segments. Shortening in these segments continued 58 +/- 14 ms after aortic valve closure, during which circumferential shortening increased from 16.9 +/- 1.2% to 20.0 +/- 1.5%. Maps of the timing of contraction in normal subjects may serve as a reference in detecting mechanical asynchrony due to intraventricular conduction defects or ischemia. |
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Authors:
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J J M Zwanenburg; M J W Götte; J P A Kuijer; R M Heethaar; A C van Rossum; J T Marcus |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-01-15 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 286 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-09 Completed Date: 2004-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1872-80 Citation Subset: IM |
Affiliation:
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Department of Physics and Medical Technology, University Medical Center, VU 1007 MB Amsterdam, The Netherlands. jjm.zwanenburg@vumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aortic Valve / physiology Electrocardiography Female Heart / physiology* Humans Magnetic Resonance Imaging* / methods Male Middle Aged Myocardial Contraction / physiology* Reference Values Systole Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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