| Timing bolus dynamic contrast-enhanced (DCE) MRI assessment of hepatic perfusion: Initial experience. | |
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MedLine Citation:
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PMID: 19472388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess whether dynamic contrast-enhanced (DCE) MRI timing bolus data from routine clinical examinations can be postprocessed to obtain hepatic perfusion parameters for diagnosing cirrhosis. MATERIALS AND METHODS: We retrospectively identified 57 patients (22 with cirrhosis and 35 without cirrhosis) who underwent abdominal MRI, which included a low-dose (2 mL gadodiamide) timing bolus using a volumetric spoiled gradient echo T1-weighted sequence through the abdomen. Using a dual-input single-compartment model, the following perfusion parameters were measured: arterial, portal, and total blood flow; arterial fraction; mean transit time; and distribution volume. Those parameters were compared between patients with and without cirrhosis using t-tests. Receiver operating characteristic (ROC) curve analysis was used to identify the perfusion parameters that can best predict the presence of cirrhosis. RESULTS: The hepatic arterial fraction, arterial flow, and distribution volume in patients with cirrhosis (27.7 +/- 8.3%, 44.8 +/- 14.1 mL/minute/100 g, and 16.3 +/- 4.5%, respectively) were significantly higher than those without cirrhosis (18.7 +/- 4.4%, 28.5 +/- 11.7 mL/minute/100 g, and 14.0 +/- 4.2%, respectively; P < 0.05 for all). ROC analysis showed arterial fraction as the best predictor of cirrhosis, with sensitivity of 73% and specificity of 86%. CONCLUSION: Timing bolus DCE MR images from routine examinations can be postprocessed to yield potentially useful hepatic perfusion parameters. |
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Authors:
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Simon Baxter; Zhen J Wang; Bonnie N Joe; Aliya Qayyum; Bachir Taouli; Benjamin M Yeh |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 29 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1317-22 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of California, San Francisco, San Francisco, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Contrast Media / administration & dosage* Female Gadolinium DTPA / administration & dosage* Humans Image Interpretation, Computer-Assisted Injections, Intravenous Liver / blood supply* Liver Cirrhosis / diagnosis* Magnetic Resonance Imaging / methods* Male Middle Aged ROC Curve Retrospective Studies Sensitivity and Specificity Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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1 T32 EB00161/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 122795-43-1/gadodiamide; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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