Document Detail


Timing of allergy-preventive and immunomodulatory dietary interventions - are prenatal, perinatal or postnatal strategies optimal?
MedLine Citation:
PMID:  23414535     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The increasing allergy prevalence in affluent countries may be caused by reduced microbial stimulation and a decreased dietary ω-3/ω-6 long-chain polyunsaturated fatty acid (LCPUFA) ratio, resulting in an abnormal postnatal immune maturation. The timing of allergy-preventive probiotic and ω-3 LCPUFA interventions is critical, as early-life events occurring during critical windows of immune vulnerability can have long-term impact on immune development. The maternal dietary and microbial environment during pregnancy may programme the immune development of the child. Prenatal environmental exposures may alter gene expression via epigenetic mechanisms, aiming to induce physiological adaptations to the anticipated postnatal environment, but potentially also increasing disease susceptibility in the offspring if exposures are mismatched. Although the importance of fetal programming mostly has been studied in cardiovascular and metabolic disease, this hypothesis is also very attractive in the context of environmentally influenced immune-mediated diseases. This review focuses on how prenatal, perinatal or postnatal ω-3 LCPUFA interventions regulate childhood immune and allergy development, and if synergistic effects may be obtained by simultaneous probiotic supplementation. We propose that combined pre- and postnatal preventive measures may be most efficacious. Increasing knowledge on the immunomodulatory effects of prenatal, perinatal and postnatal interventions will help to direct future strategies to combat the allergy epidemic.
Authors:
M C Jenmalm; K Duchén
Related Documents :
22141755 - Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostag...
12546135 - Morphine-induced enhancement in the granulocyte response to thioglycollate administrati...
21886625 - Role of micrornas in insect host-microorganism interactions.
15909305 - Ceacam1 (cd66a) mediates delay of spontaneous and fas ligand-induced apoptosis in granu...
16906225 - Impaired clearance of apoptotic cardiocytes is linked to anti-ssa/ro and -ssb/la antibo...
24034105 - Inhibition of p38 activity reverses claudin-6 induced cell apoptosis, invasion, and mig...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  43     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Division of Inflammation Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification of Aroma Active Compounds of Cereal Coffee Brew and Its Roasted Ingredients.
Next Document:  Evaluation of the adult patient with atopic dermatitis.