| Timing of solid food introduction and risk of obesity in preschool-aged children. | |
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MedLine Citation:
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PMID: 21300681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the association between timing of introduction of solid foods during infancy and obesity at 3 years of age. METHODS: We studied 847 children in Project Viva, a prospective pre-birth cohort study. The primary outcome was obesity at 3 years of age (BMI for age and gender ≥ 95th percentile). The primary exposure was the timing of introduction of solid foods, categorized as <4, 4 to 5, and ≥ 6 months. We ran separate logistic regression models for infants who were breastfed for at least 4 months ("breastfed") and infants who were never breastfed or stopped breastfeeding before the age of four months ("formula-fed"), adjusting for child and maternal characteristics, which included change in weight-for-age z score from 0 to 4 months-a marker of early infant growth. RESULTS: In the first 4 months of life, 568 infants (67%) were breastfed and 279 (32%) were formula-fed. At age 3 years, 75 children (9%) were obese. Among breastfed infants, the timing of solid food introduction was not associated with odds of obesity (odds ratio: 1.1 [95% confidence interval: 0.3-4.4]). Among formula-fed infants, introduction of solid foods before 4 months was associated with a sixfold increase in odds of obesity at age 3 years; the association was not explained by rapid early growth (odds ratio after adjustment: 6.3 [95% confidence interval: 2.3-6.9]). CONCLUSIONS: Among formula-fed infants or infants weaned before the age of 4 months, introduction of solid foods before the age of 4 months was associated with increased odds of obesity at age 3 years. |
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Authors:
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Susanna Y Huh; Sheryl L Rifas-Shiman; Elsie M Taveras; Emily Oken; Matthew W Gillman |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-02-07 |
Journal Detail:
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Title: Pediatrics Volume: 127 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-02 Completed Date: 2011-05-10 Revised Date: 2012-09-19 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e544-51 Citation Subset: AIM; IM |
Affiliation:
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Division of Gastroenterology and Nutrition, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA. susanna.huh@childrens.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Development Child, Preschool Feeding Methods* Female Follow-Up Studies Humans Incidence Infant Infant Food / standards* Male Obesity / epidemiology*, prevention & control Prospective Studies Risk Factors United States / epidemiology Weaning* |
| Grant Support | |
ID/Acronym/Agency:
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HD34568/HD/NICHD NIH HHS; HD64925/HD/NICHD NIH HHS; HL68041/HL/NHLBI NIH HHS; P30 DK040561-15/DK/NIDDK NIH HHS |
| Comments/Corrections | |
Comment In:
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Evid Based Med. 2011 Dec;16(6):177-8
[PMID:
21628387
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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