Document Detail


Timing of solid food introduction and risk of obesity in preschool-aged children.
MedLine Citation:
PMID:  21300681     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the association between timing of introduction of solid foods during infancy and obesity at 3 years of age.
METHODS: We studied 847 children in Project Viva, a prospective pre-birth cohort study. The primary outcome was obesity at 3 years of age (BMI for age and gender ≥ 95th percentile). The primary exposure was the timing of introduction of solid foods, categorized as <4, 4 to 5, and ≥ 6 months. We ran separate logistic regression models for infants who were breastfed for at least 4 months ("breastfed") and infants who were never breastfed or stopped breastfeeding before the age of four months ("formula-fed"), adjusting for child and maternal characteristics, which included change in weight-for-age z score from 0 to 4 months-a marker of early infant growth.
RESULTS: In the first 4 months of life, 568 infants (67%) were breastfed and 279 (32%) were formula-fed. At age 3 years, 75 children (9%) were obese. Among breastfed infants, the timing of solid food introduction was not associated with odds of obesity (odds ratio: 1.1 [95% confidence interval: 0.3-4.4]). Among formula-fed infants, introduction of solid foods before 4 months was associated with a sixfold increase in odds of obesity at age 3 years; the association was not explained by rapid early growth (odds ratio after adjustment: 6.3 [95% confidence interval: 2.3-6.9]).
CONCLUSIONS: Among formula-fed infants or infants weaned before the age of 4 months, introduction of solid foods before the age of 4 months was associated with increased odds of obesity at age 3 years.
Authors:
Susanna Y Huh; Sheryl L Rifas-Shiman; Elsie M Taveras; Emily Oken; Matthew W Gillman
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-02-07
Journal Detail:
Title:  Pediatrics     Volume:  127     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-05-10     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e544-51     Citation Subset:  AIM; IM    
Affiliation:
Division of Gastroenterology and Nutrition, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA. susanna.huh@childrens.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Child Development
Child, Preschool
Feeding Methods*
Female
Follow-Up Studies
Humans
Incidence
Infant
Infant Food / standards*
Male
Obesity / epidemiology*,  prevention & control
Prospective Studies
Risk Factors
United States / epidemiology
Weaning*
Grant Support
ID/Acronym/Agency:
HD34568/HD/NICHD NIH HHS; HD64925/HD/NICHD NIH HHS; HL68041/HL/NHLBI NIH HHS; P30 DK040561-15/DK/NIDDK NIH HHS
Comments/Corrections
Comment In:
Evid Based Med. 2011 Dec;16(6):177-8   [PMID:  21628387 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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