Document Detail

Timing of the introduction of complementary foods in infancy: a randomized controlled trial.
MedLine Citation:
PMID:  23147979     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To increase knowledge on iron status and growth during the first 6 months of life. We hypothesized that iron status would be better in infants who received complementary foods in addition to breast milk compared with those exclusively breastfed.
METHODS: One hundred nineteen healthy term (≥37 weeks) singleton infants were randomly assigned to receive either complementary foods in addition to breast milk from age 4 months (CF) or to exclusive breastfeeding for 6 months (EBF). Dietary data were collected by 3-day weighed food records, and data on iron status and growth were also collected.
RESULTS: One hundred infants (84%) completed the trial. Infants in the CF group had higher mean serum ferritin levels at 6 months (P = .02), which remained significant when adjusted for baseline characteristics. No difference was seen between groups in iron deficiency anemia, iron deficiency, or iron depletion. The average daily energy intake from complementary foods of 5-month-olds in the CF group was 36.8 kJ per kg body weight. Infants in both groups grew at the same rate between 4 and 6 months of age.
CONCLUSIONS: In a high-income country, adding a small amount of complementary food in addition to breast milk to infants' diets from 4 months of age does not affect growth rate between 4 and 6 months, but has a small and positive effect on iron status at 6 months. The biological importance of this finding remains to be determined.
Olof H Jonsdottir; Inga Thorsdottir; Patricia L Hibberd; Mary S Fewtrell; Jonathan C Wells; Gestur I Palsson; Alan Lucas; Geir Gunnlaugsson; Ronald E Kleinman
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-11-12
Journal Detail:
Title:  Pediatrics     Volume:  130     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-04     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1038-45     Citation Subset:  AIM; IM    
Unit for Nutrition Research, Landspitali, The National University Hospital of Iceland, University of Iceland, Reykjavik, Iceland.
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MeSH Terms
Age Factors
Anemia, Iron-Deficiency / blood,  prevention & control*
Body Height / physiology*
Body Weight / physiology*
Breast Feeding*
Erythrocyte Indices
Ferritins / blood
Infant Nutritional Physiological Phenomena / physiology*
Iron, Dietary / administration & dosage
Nutritional Requirements
Grant Support
Reg. No./Substance:
0/Iron, Dietary; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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