Document Detail

Timescales of genetic and epigenetic inheritance.
MedLine Citation:
PMID:  17320504     Owner:  NLM     Status:  MEDLINE    
According to classical evolutionary theory, phenotypic variation originates from random mutations that are independent of selective pressure. However, recent findings suggest that organisms have evolved mechanisms to influence the timing or genomic location of heritable variability. Hypervariable contingency loci and epigenetic switches increase the variability of specific phenotypes; error-prone DNA replicases produce bursts of variability in times of stress. Interestingly, these mechanisms seem to tune the variability of a given phenotype to match the variability of the acting selective pressure. Although these observations do not undermine Darwin's theory, they suggest that selection and variability are less independent than once thought.
Oliver J Rando; Kevin J Verstrepen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cell     Volume:  128     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-03-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  655-68     Citation Subset:  IM    
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
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MeSH Terms
Epigenesis, Genetic / genetics*
Gene Expression Regulation / genetics
Genetic Variation / genetics*
Inheritance Patterns / genetics*
Mutation / genetics
Time Factors
Grant Support
5P50 GM068763-01/GM/NIGMS NIH HHS

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