Document Detail

Timeline of key events in snake venom metalloproteinase research.
MedLine Citation:
PMID:  19344655     Owner:  NLM     Status:  MEDLINE    
It is reasonable to state that snake venom toxinology has been actively pursued for at least the past 400 to 500 years. Early on it was appreciated that the venoms of the Viperidae produced profound local effects, notably hemorrhage. For the past 100 years, with the advent of modern chemistry and biochemistry significant progress has been gained regarding the function, structure and role of the snake venom metalloproteinases (SVMPs) in viperid venom pathogenesis. In this review we provide a concise, chronological presentation of the key significant studies that have led to our current understanding of these intriguing toxins.
Jay W Fox; Solange M T Serrano
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Publication Detail:
Type:  Historical Article; Journal Article; Review     Date:  2009-01-21
Journal Detail:
Title:  Journal of proteomics     Volume:  72     ISSN:  1874-3919     ISO Abbreviation:  -     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101475056     Medline TA:  J Proteomics     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  200-9     Citation Subset:  IM    
Deparment of Microbiology, University of Virginia, Charlottesville, VA 22908-0734, USA.
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MeSH Terms
Evolution, Molecular
History, 19th Century
History, 20th Century
History, 21st Century
Metalloproteases / analysis,  chemistry*
Metals / chemistry
Protein Conformation
Proteomics / history*,  methods
Snake Venoms / analysis*,  chemistry
Substrate Specificity
Reg. No./Substance:
0/Metals; 0/Snake Venoms; EC 3.4.-/Metalloproteases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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